Dehydroepiandrosterone as a regulator of immune cell function
Dehydroepiandrosterone as a regulator of immune cell function
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DOI：
10.1016/j.jsbmb.2009.12.016
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发表时间：
2010-05-31
影响因子：
4.1
通讯作者：
Lord, Janet M.
中科院分区：
文献类型：
--
作者：
Hazeldine, Jon;Arlt, Wiebke;Lord, Janet M.
脱氢表雄酮（DHEA）是一种源自肾上腺的C19类固醇。值得注意的是，它的分泌会随着年龄的增长而减少，这种现象被称为“肾上腺素暂停”。多年来，DHEA的生理意义仍然难以捉摸。然而，现在许多研究表明脱氢表雄酮具有显著的免疫调节功能，表现出免疫刺激和抗糖皮质激素的作用。尽管这些研究中有几项是在啮齿动物身上进行的，这些啮齿动物不能产生肾上腺脱氢表雄酮，因此这种类固醇的循环水平很低，但来自免疫细胞研究的证据现在越来越多地表明脱氢表雄酮在调节人体免疫力方面的作用。这种调节免疫功能的能力引起了人们对DHEA治疗潜力的兴趣，DHEA可用于治疗这种激素循环水平低的受试者出现的免疫异常。这包括试图逆转老年人对疫苗接种受损的免疫反应，以及恢复慢性自身免疫性疾病患者的免疫调节。本文综述了DHEA对免疫功能的影响，并讨论了这种类固醇在老年医学中的治疗潜力，特别是在与免疫成分相关的年龄相关疾病中。(C) 2010 Elsevier Ltd.版权所有。
Dehydroepiandrosterone (DHEA) is a C19 steroid of adrenal origin. Notably, its secretion declines with age, a phenomenon referred to as the "adrenopause". For many years, the physiological significance of DHEA remained elusive. However, many studies have now shown that DHEA has significant immune modulatory function, exhibiting both immune stimulatory and anti-glucocorticoid effects. Although several of these studies are limited by the fact that they were carried out in rodents, who are incapable of adrenal DHEA production, and therefore have very low circulating levels of this steroid, evidence from the study of immune cells is now accumulating to suggest a role for DHEA in regulating human immunity. This ability to regulate immune function has raised interest in the therapeutic potential of DHEA as a treatment for the immunological abnormalities that arise in subjects with low circulating levels of this hormone. This has included attempts at reversing the impaired immune response of older individuals to vaccination and restoring immune regulation in patients with chronic autoimmune disease. This review summarises the reported effects of DHEA on immune function and discusses the therapeutic potential of this steroid in geriatric medicine and particularly in age-related disease with an immune component. (C) 2010 Elsevier Ltd. All rights reserved.