Self-assembly of amphiphilic peptides: Effects of the single-chain-to-gemini structural transition and the side chain groups
Self-assembly of amphiphilic peptides: Effects of the single-chain-to-gemini structural transition and the side chain groups
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两亲性肽的自组装：单链到双子结构转变和侧链基团的影响
DOI：
10.1016/j.colsurfa.2015.01.044
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发表时间：
2015-03-20
影响因子：
5.2
通讯作者：
Xu, Hai
中科院分区：
文献类型：
--
作者：
Cao, Meiwen;Cao, Changhai;Xu, Hai
通过设计含半胱氨酸的单链肽，然后通过氧化将两个这样的分子通过二硫键连接，成功合成了一系列两亲性双子肽。双子座几何结构不仅引入了分子构象的额外限制，而且还引入了不同的分子内和分子间氢键。这些方面导致了自组装行为的特定转变。单链肽倾向于形成球形聚集体，而双子分子均自组装成纤维状结构，特别是I3C-CI3可以形成高度有序的横向排列的短细纤维，这是罕见的。此外，单链肽和双子肽的自组装都表现出对侧链基团的极大依赖性。随着侧链烷基尺寸的增加，分子的临界聚集浓度（CAC）降低，并且更容易排列成有序的组装体。这应该归因于疏水相互作用的增强和随后的力平衡变化。 (C) 2015 Elsevier B.V. 保留所有权利。
By designing cysteine-containing single-chain peptides and then linking two such molecules with disulfide bond under oxidation, a series of amphiphilic gemini peptides were successfully synthesized. The gemini geometry introduced not only additional constraints in molecular conformations but also the differentiated intra- and intermolecular hydrogen bonding. These aspects result in specific transition of the self-assembly behavior. The single-chain peptides tended to form spherical aggregates, while the gemini molecules all self-assembled into fiber-like structures, especially that I3C-CI3 could form short thin fibers with highly ordered lateral alignments that are rarely found. Moreover, the self-assembly of both the single-chain and the gemini peptides showed great dependence on the side chain groups. With increasing the size of the side chain alkyl groups, the molecules gave decreased critical aggregation concentration (CAC) and were more ready to arrange into ordered assemblies. This should be ascribed to the enhanced hydrophobic interaction and the subsequent force balance shifts. (C) 2015 Elsevier B.V. All rights reserved.