Regulating the Conformation of Methylazacalix[6]pyridine by Oligonucleotide BCL-2 2345 and Its Recognition of Hydroxymethylpiperazinofullerene
Regulating the Conformation of Methylazacalix[6]pyridine by Oligonucleotide BCL-2 2345 and Its Recognition of Hydroxymethylpiperazinofullerene
复制标题
寡核苷酸BCL-2 2345调控甲基氮杂花[6]吡啶的构象及其对羟甲基哌嗪富勒烯的识别
DOI：
10.1021/jz201539s
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发表时间：
2012-01-05
影响因子：
5.7
通讯作者：
Tang, Ya-Lin
中科院分区：
文献类型：
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作者：
Guan, Ai-Jiao;Zhang, En-Xuan;Tang, Ya-Lin
杯芳烃由于其灵活的构象、空穴结构、多样的识别性能和功能，在分子识别领域受到了广泛的关注。然而，杯芳烃的构象控制仍然是杯芳烃研究领域的一个具有挑战性的课题。因此，我们探索了通过DNA模板控制非手性杯芳烃甲基氮杂杯[6]吡啶（简称MACP 6）手性的可能性。我们发现，通过控制bcl-2 2345 DNA的二级结构，可以获得具有相反手性的MACP 6。此外，不同手性的112）3 MACP 6被用来识别水溶液中的富勒烯衍生物。这些结果为手性杯芳烃的合成提供了一条可能的途径。
Calixaromatics have attracted much attention on molecular recognition owing to their flexible conformations, cavity structures, versatile recognition properties, and functions. However, conformational control of calixaromatics is still a challenging topic in the field of calixaromatics. Therefore, we explore the possibility to control the chirality of achiral calixaromatics, methylazacalix[6]pyridine (abbreviated as MACP6), by templating of DNA. We have found that MACP6 with opposite chirality can be achieved by controlling the secondary structure of bcl-2 2345 DNA. Furthermore, 112)3 MACP6 with different chirality has been used to recognize fullerene derivatives in aqueous solution. Our results have provided a possible approach to construct chiral calixaromatics.