Biomarkers for diagnosis and monitoring of Celiac disease.
Biomarkers for diagnosis and monitoring of Celiac disease.
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用于诊断和监测乳糜泻的生物标志物。
DOI：
10.1097/mcg.0b013e31827874e3
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
M.
中科院分区：
文献类型：
--
作者：
Vives-Pi;M.
乳糜泻（CD）是一种自身免疫性疾病，它损害小肠，是由遗传易感个体摄入麸质引起的。唯一已知有效的治疗方法是终生无谷蛋白饮食。遗传风险因素已经确定，几乎所有患者都是HLA-DQ2和/或HLA-DQ8阳性。特异性自身抗体，IgA抗组织转谷氨酰胺酶-2，抗肌内膜和抗脱氨形式的麦胶蛋白肽抗体，被广泛用作乳糜泻患者的诊断辅助手段。然而，新的生物标志物的发现可能有助于疾病的诊断和随访。最近，参与组织再生的REG Iα分子被认为是乳糜泻的一种新的生物标志物。在乳糜泻患者损伤和炎症期间，REG Iα在靶组织和血清中的表达增加，在无麸质饮食后表达减少。本文综述了用于诊断和监测乳糜泻的主要生物标志物，重点介绍了免疫反应相关机制。
Celiac disease (CD) is an autoimmune disorder, which damages the small intestine and is caused by ingestion of gluten in genetically susceptible individuals. The only known effective treatment is a lifelong gluten-free diet. Genetic risk factors have been identified and nearly all patients are HLA-DQ2 and/or HLA-DQ8 positive. Specific autoantibodies, IgA antitissue transglutaminase-2, antiendomysium, and antideaminated forms of gliadin peptide antibodies, are widely used as diagnostic aids in celiac patients. However, the discovery of new biomarkers may help in the diagnosis and follow-up of the disease. Recently, the molecule REG Iα, involved in tissue regeneration, has been proposed as a new biomarker of CD. REG Iα expression is increased in the target tissue and in the sera of celiac patients during damage and inflammation, decreasing after gluten-free diet. In this article we review the main biomarkers for diagnosis and monitoring of CD, focusing on the immune response–related mechanisms.