Serum levels of adiponectin and IGFBP-1 in short children born small for gestational age
Serum levels of adiponectin and IGFBP-1 in short children born small for gestational age
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DOI：
10.1111/j.1365-2265.2006.02724.x
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发表时间：
2007-02-01
影响因子：
3.2
通讯作者：
Matsui, Akira
中科院分区：
文献类型：
--
作者：
Kamoda, Tomohiro;Nozue, Hiroki;Matsui, Akira
目的本研究的目的是量化短胎龄儿（SGA）与适胎龄儿（AGA）的血清脂联素浓度，并评估血清脂联素水平与胰岛素样生长因子结合蛋白-1 （IGFBP-1）之间的关系，IGFBP-1被称为2型糖尿病和心血管疾病的发展预测因子。研究对象与方法选取年龄、体质指数、身高、青春期状态、胎龄、骨龄、父母中间身高相匹配的青春期前矮个子SGA儿童16例和AGA出生矮个子儿童20例。空腹状态下测定血清脂联素、IGFBP-1、胰岛素和胰岛素样生长因子-1 （IGF-I）水平。结果SGA患儿血清脂联素水平显著低于AGA患儿（10.5 +/- 4.2 vs. 13.9 +/- 5.1 mu g/ml, P < 0.05）。两组血清IGFBP-1、胰岛素和igf -1水平均相似。总体而言，脂联素与IGFBP-1呈显著正相关（r = 0.40, P < 0.05）。结论低脂联素血症在没有追赶性生长的短SGA儿童中可能反映了胰岛素抵抗，暗示了发展为2型糖尿病的高风险。此外，在短SGA儿童中，脂联素可能是比IGFBP-1更敏感的潜在胰岛素抵抗指标。
Objective The aim of this study was to quantify serum adiponectin concentrations in short children born small for gestational age (SGA) compared with those in children born appropriate for gestational age (AGA), and to assess the relationship between the serum levels of adiponectin and insulin-like growth factor binding protein-1 (IGFBP-1) known as a predictor of the development of type 2 diabetes mellitus and cardiovascular disease.Subjects and methods Sixteen prepubertal short children born SGA and 20 short children born AGA, matched for age, body mass index, height, pubertal status, gestational age, bone age and midparental height, were included in the study. The serum levels of adiponectin, IGFBP-1, insulin and insulin-like growth factor-I (IGF-I) were measured in the fasting state.Results The levels of serum adiponectin were significantly lower in the SGA than in AGA children (10.5 +/- 4.2 vs. 13.9 +/- 5.1 mu g/ml, P < 0.05). The levels of serum IGFBP-1, insulin and IGF-I were all similar in both groups. Overall, there was a significant positive correlation between adiponectin and IGFBP-1 (r = 0.40, P < 0.05).Conclusions Our results suggest that hypoadiponectinaemia in short SGA children without catch-up growth may reflect insulin resistance and imply a higher risk of developing type 2 diabetes mellitus. Additionally, adiponectin may be a more sensitive indicator for latent insulin resistance than IGFBP-1 in short SGA children.