Performance evaluation of a mouse-sized camera for dynamic studies in small animals
Performance evaluation of a mouse-sized camera for dynamic studies in small animals
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DOI：
10.1016/j.nima.2006.10.026
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发表时间：
2007-02-01
影响因子：
1.4
通讯作者：
Varvarigou, Alexandra
中科院分区：
文献类型：
--
作者：
Loudos, George;Majewski, Stan;Varvarigou, Alexandra
一个鼠标大小的相机已经建立在演示机构之间的合作。该系统用于在小动物中进行动态研究，以评价新型放射性药物。探测器的有效面积约为48 x 96 mm，可在单个视图中描绘整个鼠标。该系统是基于两个平板滨松H8500位置敏感光电倍增管（PSPMT），像素化的碘化钠（铊）闪烁体和铜铍（CuBe）平行孔准直器。在这项工作中，该系统的评价结果，使用幻影和小动物注射常规放射性药物。准直器表面上的平均分辨率类似于1.6 mm，在距离探测器12 cm处增加到类似于4.1 mm。测量了平均能量分辨率，发现对Tc（99 m）的平均能量分辨率为15.6%。从成像薄毛细管的结果表明，系统的高分辨率和灵敏度的活动变化。用~（99 m）Tc-DTPA和~（99 m）Tc-MDP对小动物进行了初步的动态研究。结果表明，该系统的能力，在小动物进行动态成像。(c)2006年由Elsevier B. V.出版
A mouse sized camera has been built in terms of collaboration between the presenting institutions. The system is used for the performance of dynamic studies in small animals, in order to evaluate novel radiopharmaceuticals. The active area of the detector is approximately 48 x 96 mm allowing depiction of the entire mouse in a single view. The system is based on two flat-panel Hamamatsu H8500 position sensitive photomultiplier tubes (PSPMT), a pixellated NaI(Tl) scintillator and a copper-beryllium (CuBe) parallel-hole collimator. In this work, the evaluation results of the system are presented, using phantoms and small animals injected with conventional radiophrmaceuticals. Average resolution was similar to 1.6 mm on the collimator surface and increased to similar to 4.1 mm in 12cm distance from the detector. The average energy resolution was measured and found to be similar to 15.6% for Tc(99m). Results from imaging thin capillaries demonstrated system's high resolution and sensitivity in activity variations was shown. Initial dynamic studies have been carried out in small animals injected with Tc(99m)-DTPA and Tc(99m)-MDP. The results show system's ability to perform kinetic imaging in small animals. (c) 2006 Published by Elsevier B.V.