Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS
Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS
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DOI：
10.1212/wnl.0000000000000775
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发表时间：
2014-09-09
期刊：
影响因子：
9.9
通讯作者：
Vandenborne, Krista
中科院分区：
文献类型：
--
作者：
Arpan, Ishu;Willcocks, Rebecca J.;Vandenborne, Krista
目的：目的：应用磁共振成像（MRI）和磁共振波谱（MRS）技术评价激素对Duchenne型肌营养不良（DMD）患儿下肢肌肉的影响。方法：应用MRI/MRS技术检测15例DMD患儿（年龄5.0-6.9岁）和15例未用激素患儿下肢肌肉的横向弛豫时间（T2）和脂肪含量。随后，在这些男孩的一个子集中测量1岁时的脂肪分数。最后，在基线、3个月和6个月时，从16名未接受过皮质类固醇治疗的DMD男孩（年龄5 - 8.9岁）中收集MRI/MRS数据。五个男孩接受皮质类固醇治疗后，基线和其余11个作为皮质类固醇-幼稚controls.Results：横截面比较显示较低的肌肉T2和肌内（IM）脂肪沉积在DMD的男孩皮质类固醇，这表明减少炎症/损伤和脂肪浸润治疗。接受皮质类固醇治疗的男孩在1年时IM脂肪浸润增加较少。最后，T2的MRI/MRS检测到的影响，皮质类固醇对腿部肌肉早在3个月后，药物initiation.Conclusions：这些结果表明，MRI/MRS的能力，以检测治疗效果的皮质类固醇在减少炎症过程中的骨骼肌的男孩DMD。我们的工作突出了MRI/MRS作为评估DMD治疗干预的生物标志物的潜力。
Objective: To evaluate the effects of corticosteroids on the lower extremity muscles in boys with Duchenne muscular dystrophy (DMD) using MRI and magnetic resonance spectroscopy (MRS).Methods: Transverse relaxation time (T2) and fat fraction were measured by MRI/MRS in lower extremity muscles of 15 boys with DMD (age 5.0-6.9 years) taking corticosteroids and 15 corticosteroid-naive boys. Subsequently, fat fraction was measured in a subset of these boys at 1 year. Finally, MRI/MRS data were collected from 16 corticosteroid-naive boys with DMD (age 5-8.9 years) at baseline, 3 months, and 6 months. Five boys were treated with corticosteroids after baseline and the remaining 11 served as corticosteroid-naive controls.Results: Cross-sectional comparisons demonstrated lower muscle T2 and less intramuscular (IM) fat deposition in boys with DMD on corticosteroids, suggesting reduced inflammation/damage and fat infiltration with treatment. Boys on corticosteroids demonstrated less increase in IM fat infiltration at 1 year. Finally, T2 by MRI/MRS detected effects of corticosteroids on leg muscles as early as 3 months after drug initiation.Conclusions: These results demonstrate the ability of MRI/MRS to detect therapeutic effects of corticosteroids in reducing inflammatory processes in skeletal muscles of boys with DMD. Our work highlights the potential of MRI/MRS as a biomarker in evaluating therapeutic interventions in DMD.