External vibration multi-directional ultrasound shearwave elastography (EVMUSE): application in liver fibrosis staging.
External vibration multi-directional ultrasound shearwave elastography (EVMUSE): application in liver fibrosis staging.
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DOI：
10.1109/tmi.2014.2332542
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发表时间：
2014-11
影响因子：
10.6
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Zhao H;Song P;Meixner DD;Kinnick RR;Callstrom MR;Sanchez W;Urban MW;Manduca A;Greenleaf JF;Chen S
剪切波速度可用于评估与组织健康相关的组织弹性。超声剪切波弹性成像技术基于测量声辐射力引起的剪切波的传播速度，正在成为肝纤维化分期中活检的有前途的替代方法。然而，通过这种方法产生的剪切波通常非常弱。因此，穿透可能会成为问题，特别是对于超重或肥胖患者。在这项研究中，我们开发了一种新的方法，称为外部振动多方向超声剪切波弹性成像（EVMUSE），其中外部振动从扬声器被用来产生一个多方向的剪切波场。然后应用方向滤波器将复杂的剪切波场分离成多个沿不同方向传播的剪切波场。从每个单独的剪切波场重建二维（2D）剪切波速度图，并通过将这些单独的波速图复合来构建最终的2D剪切波速度图。该方法进行了验证，使用两个同质体模和一个多用途的仿组织体模。10例接受肝脏磁共振弹性成像（MRE）的患者也使用EVMUSE进行了研究，以比较两种方法之间的结果。体模结果显示EVMUSE能够准确量化组织弹性，具有良好的穿透性。体内EVMUSE结果与MRE结果具有良好的相关性，表明EVMUSE用于肝纤维化分期的前景。
Shear wave speed can be used to assess tissue elasticity, which is associated with tissue health. Ultrasound shear wave elastography techniques based on measuring the propagation speed of the shear waves induced by acoustic radiation force are becoming promising alternatives to biopsy in liver fibrosis staging. However, shear waves generated by such methods are typically very weak. Therefore, the penetration may become problematic, especially for overweight or obese patients. In this study, we developed a new method called External Vibration Multi-directional Ultrasound Shearwave Elastography (EVMUSE), in which external vibration from a loudspeaker was used to generate a multi-directional shear wave field. A directional filter was then applied to separate the complex shear wave field into several shear wave fields propagating in different directions. A two-dimensional (2D) shear wave speed map was reconstructed from each individual shear wave field, and a final 2D shear wave speed map was constructed by compounding these individual wave speed maps. The method was validated using two homogeneous phantoms and one multi-purpose tissue-mimicking phantom. Ten patients undergoing liver Magnetic Resonance Elastography (MRE) were also studied with EVMUSE to compare results between the two methods. Phantom results showed EVMUSE was able to quantify tissue elasticity accurately with good penetration. In vivo EVMUSE results were well correlated with MRE results, indicating the promise of using EVMUSE for liver fibrosis staging.