FeCl2-Mediated Regioselective Aminochlorination and Aminoazidation of Styrenes with Trifluoromethanesulfonyl Azide
FeCl2-Mediated Regioselective Aminochlorination and Aminoazidation of Styrenes with Trifluoromethanesulfonyl Azide
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FeCl2 介导的苯乙烯与三氟甲磺酰叠氮化物的区域选择性氨氯化和氨基叠氮化反应
DOI：
10.1021/acs.orglett.1c01642
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发表时间：
2021
期刊：
影响因子：
5.2
通讯作者：
Liu Wen-Bo
中科院分区：
文献类型：
--
作者：
Zhao Jing;Huang Hong-Gui;Li Weishuang;Liu Wen-Bo
以n3so2cf3为胺化试剂，fec2为氯源，描述了一种高效的苯乙烯胺氯化反应。该方法操作简单，反应条件温和，官能团相容性好，区域选择性高。本文还实现了一个使用febr2进行氨基溴化的示例。另外，苯乙烯的一锅氨氮化是通过在反应中加入叠氮化钠来实现的。并介绍了该产品的克级合成和下游衍生化反应。
An efficient aminochlorination reaction of stryenes is described using N3SO2CF3as an amination reagent and FeCl2as a chloride source. The operationally simple procedure features mild reaction conditions, good functional group compatibility, and high regioselectivity. An example of aminobromination using FeBr2is also realized. Additionally, a one-pot aminoazidation of styrenes is achieved by adding sodium azide to the reaction. The gram-scale synthesis and downstream derivatization of the products are showcased as well.