Obesity in Hypertension: The Role of the Expanding Waistline Over the Years and Insights Into the Future.
Obesity in Hypertension: The Role of the Expanding Waistline Over the Years and Insights Into the Future.
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高血压中的肥胖：多年来腰围不断扩大的作用以及对未来的洞察。
DOI：
10.1161/hypertensionaha.123.21719
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Whaley-Connell,AdamT
中科院分区：
文献类型：
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作者：
Jia,Guanghong;Sowers,JamesR;Whaley-Connell,AdamT
近几十年来，肥胖症的发病率在地球仪上急剧增加，特别是在青年中，这预示着糖尿病和高血压等慢性疾病的进程。全球扩张是为了方便获得廉价、高热量的加工食品和有助于久坐生活方式的改进技术。在此背景下，世界肥胖联合会2023年报告预测，到2035年，世界上51%的人，即超过40亿人将肥胖或超重。来自疾病控制和预防中心的数据显示，近一半的美国成年人将肥胖，其中2030年将有四分之一的人严重肥胖。肥胖的负担在某些人群中不成比例地产生，这些人群受到种族、民族或精神疾病的影响。超重和肥胖被认为是胰岛素抵抗、2型糖尿病和重要的高血压发展的重要危险因素。1，2肥胖和高血压之间的关系早在世纪初就被认识到，后来在1967年的心脏病研究中得到了前瞻性的证实。3在这方面，来自法国的数据支持78%的男性和65%的女性原发性高血压可归因于超重或肥胖。3这种关系是连续分级的，即使体重增加5%，高血压的发病率也会增加20%至30%。④早期临床观察表明，肥胖的胰岛素抵抗、代谢并发症、心血管并发症在患者中较为常见
In recent decades, the incidence of obesity has increased dramatically across the globe, especially among youth that portend chronic disease processes, such as diabetes and hypertension. The global expansion has been in response to easy access to inexpensive, high-caloric, processed food and improved technologies that contribute to a sedentary lifestyle. In this context, the World Obesity Federation 2023 report predicts that 51% of the world, or> 4 billion people, will be obese or overweight by 2035. Data from the Centers for Disease Control and Prevention indicate nearly half of US adults will be obese, including≈ 1 in 4 who will have severe obesity by 2030. The burden of obesity is born disproportionately by certain population groups with racial, ethnic, or mental illness influences.Overweight and being obese has been regarded as an important risk factor in the development of insulin resistance, type 2 diabetes, and importantly hypertension. 1, 2 The relationship between obesity and hypertension has long been recognized since the beginning of the 20th century and later demonstrated prospectively in the Framingham Heart Study in 1967. 3 In this regard, data from the Framingham support that 78% of primary hypertension in men and 65% in women is attributable to overweight or obesity. 3 This relationship is continuously graded where even a 5% increase in body weight is associated with a 20% to 30% increase in the incidence of hypertension. 4 Early clinical observations indicated that insulin resistance, metabolic complications, and cardiovascular complications of obesity are more common in patients