In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits
In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits
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DOI：
10.1016/j.jep.2007.10.039
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发表时间：
2008-02-28
影响因子：
5.4
通讯作者：
Yardibi, Hasret
中科院分区：
文献类型：
--
作者：
Bakirel, Tuelay;Bakirel, Utku;Yardibi, Hasret
迷迭香（Rosmarinus officinalis）在土耳其传统民间医学中用于治疗高血糖，被广泛认为是具有最高抗氧化活性的药草之一。因此，本研究旨在研究迷迭香叶乙醇提取物对兔子葡萄糖稳态和抗氧化防御的可能作用。在第一组实验中，在血糖正常和血糖高的兔子中检查了口服不同剂量（50、100和200 mg/kg）提取物的降血糖作用。在剂量为 200 mg/kg 的提取物的两个动物组中均观察到最佳效果，并且该活性与胰岛素的作用无关。在另一部分实验中，研究了不同剂量的迷迭香提取物对四氧嘧啶诱发的糖尿病兔的血糖和血清胰岛素水平的急性影响。在三种剂量的提取物中，最高剂量（200 mg/kg）显着降低了四氧嘧啶糖尿病兔子的血糖水平并增加了血清胰岛素浓度。最后一组实验旨在研究迷迭香提取物对四氧嘧啶糖尿病兔重复给药的亚急性影响。在100和200 mg/kg的剂量下，提取物的降血糖作用伴随着糖尿病兔血清胰岛素水平的显着升高。此外，用200mg/kg剂量的提取物治疗糖尿病兔1周期间表明，提取物具有抑制脂质过氧化和激活抗氧化酶的能力。结论是，迷迭香提取物可能由于其有效的抗氧化特性而发挥显着的抗糖尿病作用。 (C) 2007 Elsevier Ireland Ltd. 保留所有权利。
Rosemary (Rosmarinus officinalis), used in traditional Turkish folk medicine for the treatment of hyperglycaemia, is widely accepted as one of the medicinal herb with the highest antioxidant activity. Accordingly, the present study was designed to investigate the possible actions of ethanolic extract of the leaves of Rosmarinus officinalis on glucose homeostasis and antioxidant defense in rabbits. In the first set of experiments, hypoglycaemic effects of oral administration of various doses (50, 100 and 200 mg/kg) of the extract were examined in normoglycaemic and glucose-hyperglycaemic rabbits. Optimal effect was observed in both of the animal groups with a dose of 200 mg/kg of the extract and this activity was independent from the effects of insulin. In another part of experiments, acute effect of various doses of the Rosmarinus officinalis extract on blood glucose and serum insulin levels was studied in alloxan-induced diabetic rabbits. Of the three doses of extract, the highest dose (200 mg/kg) significantly lowered blood glucose level and increased serum insulin concentration in alloxan-diabetic rabbits. The last set of experiments designed to investigate the subacute effect of the Rosmarinus officinalis extract on repeated administration in alloxan-diabetic rabbits. At the doses of 100 and 200 mg/kg, antihyperglycaemic effect of extract was accompanied by a significant increase in serum insulin levels in diabetic rabbits. Furthermore, during 1 week of treatment of diabetic rabbits with a dose of 200 mg/kg of the extract showed that the extract possessed a capability to inhibit the lipid peroxidation and activate the antioxidant enzymes. It was concluded that probably, due to its potent antioxidant properties, the Rosmarinus officinalis extract exerts remarkable antidiabetogenic effect. (C) 2007 Elsevier Ireland Ltd. All rights reserved.