Feasibility of mapping the tissue mass corrected bioscale of cerebral metabolic rate of oxygen consumption using 17-oxygen and 23-sodium MR imaging in a human brain at 9.4 T
Feasibility of mapping the tissue mass corrected bioscale of cerebral metabolic rate of oxygen consumption using 17-oxygen and 23-sodium MR imaging in a human brain at 9.4 T
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DOI：
10.1016/j.neuroimage.2010.02.056
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发表时间：
2010-06-01
期刊：
影响因子：
5.7
通讯作者：
Thulborn, Keith R.
中科院分区：
文献类型：
--
作者：
Atkinson, Ian C.;Thulborn, Keith R.
分子氧还原成水是氧化磷酸化的最后一步，氧化磷酸化将三磷酸腺苷的产生与葡萄糖氧化成二氧化碳过程中形成的还原当量的再氧化结合起来。这种耦合使得脑耗氧代谢率（CMRO 2）能够很好地反映大脑的代谢健康状况。提出了一种基于多核磁共振（MR）成像的CMRO 2标测方法。氧消耗量是通过应用一个新的三相代谢模型的水的产生和清除的变化17-氧（O-17）标记的水MR信号测量使用定量O-17 MR成像在吸入O-17富氧气体。这些CMRO 2数据被校正为从内源性组织钠离子的定量23-钠MR成像计算的局部脑组织质量，以获得以微摩尔O-2/g组织/分钟为单位的耗氧量的定量结果，该结果与正电子发射断层扫描报告的文献结果一致。所提出的技术证明在人脑中使用的9.4 T MR扫描仪优化人脑成像。爱思唯尔公司出版
The reduction of molecular oxygen to water is the final step of oxidative phosphorylation that couples adenosine triphosphate production to the reoxidation of reducing equivalents formed during the oxidation of glucose to carbon dioxide. This coupling makes the cerebral metabolic rate of oxygen consumption (CMRO2) an excellent reflection of the metabolic health of the brain. A multi-nuclear magnetic resonance (MR) imaging based method for CMRO2 mapping is proposed. Oxygen consumption is determined by applying a new three-phase metabolic model for water generation and clearance to the changing 17-oxygen (O-17) labeled water MR signal measured using quantitative O-17 MR imaging during inhalation of O-17-enriched oxygen gas. These CMRO2 data are corrected for the regional brain tissue mass computed from quantitative 23-sodium MR imaging of endogenous tissue sodium ions to derive quantitative results of oxygen consumption in micromoles O-2/g tissue/minute that agree with literature results reported from positron emission tomography. The proposed technique is demonstrated in the human brain using a 9.4 T MR scanner optimized for human brain imaging. Published by Elsevier Inc.