Dynamic markers of altered gait rhythm in amyotrophic lateral sclerosis
Dynamic markers of altered gait rhythm in amyotrophic lateral sclerosis
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DOI：
10.1152/jappl.2000.88.6.2045
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发表时间：
2000-06-01
影响因子：
3.3
通讯作者：
Goldberger, AL
中科院分区：
文献类型：
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作者：
Hausdorff, JM;Lertratanakul, A;Goldberger, AL
肌萎缩侧索硬化症（ALS）是一种以运动神经元缺失为特征的疾病。我们假设患有ALS的受试者将具有改变的步态节律，步幅波动的幅度和波动动力学的扰动都增加。为了测试这种运动不稳定性，我们定量地比较了ALS受试者与正常对照者以及帕金森病（PD）和亨廷顿病（HD）（基底神经节病变）受试者的步态节律。受试者以他们通常的步速行走5分钟，佩戴踝关节记录器，该记录器能够确定每个步幅的持续时间和步幅间的波动。我们发现，与健康对照组相比，ALS患者的步态不太稳定，并且在时间上更加混乱。此外，晚期ALS、HD和PD与某些常见且明显不同的步幅动力学改变特征相关。因此，步态节律的步幅到步幅控制显然与ALS有关。此外，基于步态动力学的标记物矩阵可能有助于表征运动控制的某些病理，并且可能用于定量监测疾病进展和评估治疗干预。
Amyotrophic lateral sclerosis (ALS) is a disorder marked by loss of motoneurons. We hypothesized that subjects with ALS would have an altered gait rhythm, with an increase in both the magnitude of the stride-to-stride fluctuations and perturbations in the fluctuation dynamics. To test for this locomotor instability, we quantitatively compared the gait rhythm of subjects with ALS with that of normal controls and with that of subjects with Parkinson's disease (PD) and Huntington's disease (HD), pathologies of the basal ganglia. Subjects walked for 5 min at, their usual pace wearing an ankle-worn recorder that enabled determination of the duration of each stride and of stride-to-stride fluctuations. We found that the gait of patients with ALS is less steady and more temporally disorganized compared with that of healthy controls. In addition, advanced ALS, HD, and PD were associated with certain common, as well as apparently distinct, features of altered stride dynamics. Thus stride-to-stride control of gait rhythm is apparently compromised with ALS. Moreover, a matrix of markers based on gait dynamics may be useful in characterizing certain pathologies of motor control and, possibly, in quantitatively monitoring disease progression and evaluating therapeutic interventions.