TUMOR-NECROSIS-FACTOR-ALPHA INCREASES THE UBIQUITINIZATION OF RAT SKELETAL-MUSCLE PROTEINS
TUMOR-NECROSIS-FACTOR-ALPHA INCREASES THE UBIQUITINIZATION OF RAT SKELETAL-MUSCLE PROTEINS
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DOI：
10.1016/0014-5793(93)81341-v
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发表时间：
1993-06-01
期刊：
影响因子：
3.5
通讯作者：
ARGILES, JM
中科院分区：
文献类型：
--
作者：
GARCIAMARTINEZ, C;AGELL, N;ARGILES, JM
急性静脉注射100 μ g/kg体重的重组肿瘤坏死因子-α（TNF）导致大鼠骨骼肌中游离和结合泛素水平呈时间依赖性增加。细胞因子的影响在红色比目鱼肌中比在白色肌肉EDL中更明显。在前肌肉类型，TNF治疗也导致了时间依赖性的增加，游离泛素的百分比。结果表明，泛素系统的非溶酶体蛋白降解可能有一个非常重要的作用，由TNF触发的机制，这是负责增强肌肉蛋白水解在脓毒症和其他病理状态。
An acute intravenous administration of 100 mug/kg body weight of recombinant tumour necrosis factor-alpha (TNF) resulted in a time-dependent increase in the levels of both free and conjugated ubiquitin in rat skeletal muscle. The effects of the cytokine were more pronounced in the red muscle soleus than in the white muscle EDL. In the former muscle type, TNF-treatment also resulted in a time-dependent increase in the percentage of free ubiquitin. The results suggest that the ubiquitin system for non-lysosomal protein degradation could have a very important role in the mechanism triggered by TNF which is responsible for enhanced muscle proteolysis in sepsis and other pathological states.