Pan-cancer single cell landscape of tumor-infiltrating T cells
Pan-cancer single cell landscape of tumor-infiltrating T cells
复制标题
肿瘤浸润 T 细胞的泛癌单细胞景观
DOI：
10.1126/science.abe6474
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发表时间：
2021-12-17
期刊：
影响因子：
56.9
通讯作者：
Zhang, Zemin
中科院分区：
文献类型：
--
作者：
Zheng, Liangtao;Qin, Shishang;Zhang, Zemin
T 细胞在癌症免疫治疗中发挥着核心作用，但我们缺乏对不同癌症类型的肿瘤浸润 T 细胞的异质性和动态的系统比较。我们为 21 种癌症类型的 316 名捐赠者构建了单细胞 RNA 测序泛癌 T 细胞图谱，并揭示了不同的 T 细胞组成模式。我们发现 CD8+ T 细胞耗竭时存在多种状态转换路径，以及不同肿瘤类型对这些路径的偏好。某些 T 细胞群显示出与突变负荷等患者特征的特定相关性，揭示了肿瘤微环境的可能决定因素。仅肿瘤内的 T 细胞组成就可以将癌症患者分为具有临床特征特异性的组，从而为 T 细胞免疫和针对 T 细胞的精准免疫治疗提供新的见解。
T cells play a central role in cancer immunotherapy, but we lack systematic comparison of the heterogeneity and dynamics of tumor-infiltrating T cells across cancer types. We built a single-cell RNA-sequencing pan-cancer atlas of T cells for 316 donors across 21 cancer types and revealed distinct T cell composition patterns. We found multiple state-transition paths in the exhaustion of CD8(+) T cells and the preference of those paths among different tumor types. Certain T cell populations showed specific correlation with patient properties such as mutation burden, shedding light on the possible determinants of the tumor microenvironment. T cell compositions within tumors alone could classify cancer patients into groups with clinical trait specificity, providing new insights into T cell immunity and precision immunotherapy targeting T cells.