Synthesis and evaluation as NOP ligands of some spiro[piperidine-4,2′(1′H)-quinazolin]-4′(3′H)-ones and spiro[piperidine-4,5′(6′H)[1,2,4]triazolo[1,5-c]quinazolines]
Synthesis and evaluation as NOP ligands of some spiro[piperidine-4,2′(1′H)-quinazolin]-4′(3′H)-ones and spiro[piperidine-4,5′(6′H)[1,2,4]triazolo[1,5-c]quinazolines]
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DOI：
10.1248/cpb.54.611
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发表时间：
2006-05-01
影响因子：
1.7
通讯作者：
Del Giudice, Maria Rosaria
中科院分区：
文献类型：
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作者：
Mustazza, Carlo;Borioni, Anna;Del Giudice, Maria Rosaria
合成了一些螺[哌啶-4，2 '（1' H）-喹唑啉]-4 '（3' H）-酮3和螺[哌啶-4，5 '（6' H）-[1，2，4]三唑并[1，5-c]喹唑啉] 4，并评价了它们作为痛敏素受体的配体。所检测的化合物显示部分激动活性，除了化合物3，4 n被证明是纯拮抗剂。
Some spiro[piperidine-4,2'(1'H)-quinazolin]-4'(3'H)-ones 3 and spiro[piperidine-4,5'(6'H)-[1,2,4]triazolo[1,5-c]quinazolines] 4 were synthesized and evaluated as ligands of the nociceptin receptor. The examined compounds showed partial agonistic activity, except compounds 3,4n that proved to be pure antagonists.