APOLIPOPROTEIN E4 PHENOTYPE IS NOT AN IMPORTANT RISK FACTOR FOR CORONARY HEART-DISEASE OR STROKE IN ELDERLY SUBJECTS
APOLIPOPROTEIN E4 PHENOTYPE IS NOT AN IMPORTANT RISK FACTOR FOR CORONARY HEART-DISEASE OR STROKE IN ELDERLY SUBJECTS
复制标题
DOI：
10.1161/01.atv.15.9.1280
复制
发表时间：
1995-09-01
影响因子：
8.7
通讯作者：
LAAKSO, M
中科院分区：
文献类型：
--
作者：
KUUSISTO, J;MYKKANEN, L;LAAKSO, M
在中年受试者的横断面研究中，载脂蛋白 E (ape E) 的等位基因 e4 (ape e4) 与冠心病 (CHD) 风险增加相关。我们在芬兰非糖尿病队列的一项前瞻性研究中调查了与 apo e4 等位基因数量相关的冠心病和中风风险，该队列包括 1067 名基线年龄为 65 至 74 岁的受试者。在 3.5 年的随访期间，CHD 死亡率为 2.8%，CHD 总发病率为 6.9%，CHD 累积发生率（基线患病率和 3.5 年发病率合计）为 17.0%。脑卒中发生率为3.4%，脑卒中累计发生率为6.0%。无 apo e4 等位基因的受试者 (n = 734) 的冠心病死亡率为 3.4%，有 1 个 apo e4 等位基因的受试者 (n = 296) 的冠心病死亡率为 1.7%，有 2 个 apo e4 等位基因的受试者 (n = 37) 的冠心病死亡率为 0%（三组之间的 P = NS）。根据apo e4等位基因的数量，冠心病的发生率为6.9%（无apo e4等位基因）、7.4%（1个apo e4等位基因）和2.7%（2个apo e4等位基因），冠心病的累积发生率分别为16.5%、18.6%和13.5%（P = NS）。没有 apo e4 等位基因的受试者中风的发生率为 3.8%，有 1 个 apo e4 等位基因的受试者为 2.7%，有 2 个 apo e4 等位基因的受试者为 0% (P = NS)。卒中的累积发生率分别为 6.0%、6.4% 和 2.7%（P = NS）。总之，与中年受试者相比，携带apo e4的老年受试者患心血管疾病的风险并未增加。因此，apo E的等位基因e4不能被视为老年人冠心病或中风的重要危险因素。
The allele e4 (ape e4) of apolipoprotein E (ape E) has been associated with an increased risk for coronary heart disease (CHD) in cross-sectional studies in middle-aged subjects. We investigated the risk of CHD and stroke with respect to the number of apo e4 alleles in a prospective study of a Finnish nondiabetic cohort including 1067 subjects 65 to 74 years old at baseline. During the 3.5-year follow-up, CHD mortality was 2.8%, total CHD incidence 6.9%, and the cumulative occurrence of CHD (prevalence at baseline and the 3.5-year incidence combined) 17.0%. The incidence of stroke was 3.4%, and the cumulative occurrence of stroke was 6.0%. The CHD mortality was 3.4% in subjects with no apo e4 allele (n = 734), 1.7% in those with one apo e4 allele (n = 296), and O% in subjects with two apo e4 alleles (n = 37) (P = NS between the three groups). The incidence of CHD according to the number of apo e4 alleles was 6.9% (no apo e4 alleles), 7.4% (one apo e4 allele), and 2.7% (two apo e4 alleles), and the cumulative occurrence of CHD was 16.5%, 18.6%, and 13.5%, respectively (P = NS). The incidence of stroke was 3.8% in subjects with no apo e4 allele, 2.7% in those with one apo e4 allele, and 0% in those with two apo e4 alleles (P = NS). The cumulative occurrence of stroke was 6.0%, 6.4%, and 2.7%, respectively (P = NS). In conclusion, in contrast to middle-aged subjects, the risk of cardiovascular disease in elderly subjects with apo e4 is not increased. Consequently, the allele e4 of apo E cannot be regarded as an important risk factor for CHD or stroke in the elderly.