Wnt signalling: pathway or network?
Wnt signalling: pathway or network?
复制标题
DOI：
10.1016/s0959-437x(99)80068-9
复制
发表时间：
1999-08-01
影响因子：
4
通讯作者：
Brennan, K
中科院分区：
文献类型：
--
作者：
Arias, AM;Brown, AMC;Brennan, K
分泌性糖蛋白的Wnt家族成员参与发育过程中的许多信号传导事件。最近的研究结果表明，Wnt信号有时可以在细胞命运分配过程中发挥允许的作用。Wnt蛋白已被证明与许多细胞外和细胞表面蛋白相互作用，而Wnt信号通路的许多细胞内组分也在其他细胞功能中被调用。Wnt信号传导的结果可以受到MAP激酶家族成员的影响。这些观察结果表明，未来对Wnt信号的理解可能需要基于信号网络而不是单一线性途径的模型。
Members of the Wnt family of secreted glycoproteins participate in many signalling events during development. Recent findings suggest that Wnt signals can sometimes play a permissive role during cell-fate assignment. Wnt proteins have been shown to interact with a number of extracellular and cell-surface proteins, whereas many intracellular components of the Wnt-signalling pathway are also invoked in other cellular functions. The consequences of Wnt signalling can be affected by members of the MAP kinase family. These observations suggest that the future understanding of Wnt signalling may require models that are based on a signalling network rather than a single linear pathway.