δ15N and δ13C in hair from newborn infants and their mothers: a cohort study
δ15N and δ13C in hair from newborn infants and their mothers: a cohort study
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DOI：
10.1038/pr.2012.3
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发表时间：
2012-05-01
影响因子：
3.6
通讯作者：
Hankard, Regis
中科院分区：
文献类型：
--
作者：
de Luca, Arnaud;Boisseau, Nathalie;Hankard, Regis
简介：胎儿或婴儿期的蛋白质摄入量可能在决定早期生长速度方面发挥关键作用，这是后期健康和疾病的决定因素。以前的工作表明，头发的同位素组成的饮食和蛋白质intake.METHODS的影响：本研究分析了头发的同位素组成，从239母亲/新生儿对随机选择在一个较大的队列中参加了一项研究的产前和产后的决定因素的儿童的发展和健康。结果：母亲和新生儿头发中的δ N-15含量密切相关（Pearson相关系数r = 0.88）。新生儿头发的平均Δ N-15和Δ C-13值显著高于母亲：9.7 +/- 0.7 vs. 8.8 +/- 0.6 ppm（P < 0.0001），对于δ N-13为-20.0 +/-0.4对-20.4 +/-0.4 ‰（P < 0.0001）。母亲的头发三角洲N-15在分娩时略有和正相关的估计蛋白质摄入量（r = 0.14，P = 0.04）。讨论：头发三角洲N-15的胎儿是高度依赖和系统高于母亲。无论是定量和定性的蛋白质摄入，疾病，或激素状态改变头发三角洲N-15在出生时仍有待确定。
INTRODUCTION: Protein intake in fetal life or infancy may play a key role in determining early growth rate, a determinant of later health and disease. Previous work has indicated that hair isotopic composition is influenced by diet and protein intake.METHODS: This study analyzes the isotopic composition of hair obtained from 239 mother/newborn pairs randomly selected within a larger cohort enrolled in a study of pre- and postnatal determinants of the child's development and health. The isotopic compositions in nitrogen (delta N-15) and in carbon (delta C-13) were determined by isotope ratio mass spectrometry.RESULTS: Mother and newborn hair delta N-15 were tightly correlated (Pearson r = 0.88). The mean delta N-15 and delta C-13 values of hair from newborn infants were significantly higher than those for the mothers: 9.7 +/- 0.7 vs. 8.8 +/- 0.6 parts per thousand (P < 0.0001) for delta N-15 and -20.0 +/- 0.4 vs. -20.4 +/- 0.4 parts per thousand (P < 0.0001) for delta C-13. Maternal hair delta N-15 at parturition was slightly and positively correlated with estimates of protein intake (r = 0.14, P = 0.04).DISCUSSION: Hair delta N-15 of the fetus is both highly dependent on and systematically higher than that of the mother. Whether quantitative and qualitative protein intake, disease, or hormonal status alter hair delta N-15 at birth remains to be determined.