NEUROLOGICAL MODEL FOR CHILDHOOD AUTISM
NEUROLOGICAL MODEL FOR CHILDHOOD AUTISM
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DOI：
10.1001/archneur.1978.00500360001001
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发表时间：
1978-01-01
影响因子：
--
通讯作者：
MAURER, RG
中科院分区：
文献类型：
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作者：
DAMASIO, AR;MAURER, RG
根据与成人神经病学的症状和条件的类比，提出该综合征是由双侧神经结构系统功能障碍引起的，包括位于额叶和颞叶内侧的中边缘皮层环、新纹状体和丘脑前核群和内侧核群。中脑边缘皮层在细胞结构、血管结构和神经化学上都是不同的，它与纹状体一起构成了多巴胺能中脑神经元的整个靶区。自闭症可能与这些结构中的神经介质失衡有关。这种功能障碍可能是由围产期病毒感染、脑室周围分水岭损伤或遗传决定的神经化学异常等多种原因引起的靶区或影响靶区功能的结构的宏观或微观变化的结果。
On the basis of analogy to signs and conditions seen in adult neurology, it was proposed that the syndrome results from dysfunction in a system of bilateral neural structures that includes the ring of mesolimbic cortex located in the mesial frontal and temporal lobes, the neostriatum and the anterior and medial nuclear groups of the thalamus. The mesolimbic cortex is cytoarchitectonically, angioarchitectonically and neurochemically distinct and, along with the striatum, forms the entire target area of dopaminergic mesencephalic neurons. Autism may be related to neuromediator imbalance in those structures. Such dysfunction might be the result of macroscopic or microscopic changes in the target area or in structures functionally influencing them, consequent to a variety of causes such as perinatal viral infection, insult to the periventricular watershed area or genetically determined neurochemical abnormalities.