Gastrointestinal complications of obesity: Non-alcoholic fatty liver disease (NAFLD) and its sequelae
Gastrointestinal complications of obesity: Non-alcoholic fatty liver disease (NAFLD) and its sequelae
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DOI：
10.1016/j.beem.2013.02.002
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发表时间：
2013-04-01
影响因子：
7.4
通讯作者：
Berg, Thomas
中科院分区：
文献类型：
--
作者：
Karlas, Thomas;Wiegand, Johannes;Berg, Thomas
肥胖是胃肠道恶性和非恶性疾病的主要危险因素。非酒精性脂肪性肝病（NAFLD）是代谢系统复杂病理生理学的一个突出例子，代表了代谢综合征的来源和后果。NAFLD的患病率越来越高，并将成为晚期肝病和肝硬化的主要原因。肥胖在疾病的各个方面和阶段对NAFLD都有负面影响。日益严重的流行病将使卫生保健资源紧张，并需要新的预防、筛查和治疗方法概念。更好地了解肝脏，肠道和激素系统的相互作用对于NAFLD和代谢综合征包括肥胖的潜在机制的新见解是必要的。识别有进展性肝病风险的患者将允许更好地适应治疗策略。(C)2013爱思唯尔有限公司保留所有权利。
Obesity is a major risk factor for malign and non-malign diseases of the gastrointestinal tract. Non-alcoholic fatty liver disease (NAFLD) is an outstanding example for the complex pathophysiology of the metabolic system and represents both source and consequence of the metabolic syndrome. NAFLD has a growing prevalence and will become the leading cause of advanced liver disease and cirrhosis. Obesity has a negative impact on NAFLD at all aspects and stages of the disease. The growing epidemic will strain health care resources and demands new concepts for prevention, screening and therapeutic approaches. A better understanding of the interplay of liver, gut and hormonal system is necessary for new insights in the underlying mechanisms of NAFLD and the metabolic syndrome including obesity. Identification of patients at risk for progressive liver disease will allow a better adaption of treatment strategies. (C) 2013 Elsevier Ltd. All rights reserved.