Passive imaging with pulsed ultrasound insonations
Passive imaging with pulsed ultrasound insonations
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DOI：
10.1121/1.4728230
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发表时间：
2012-07-01
影响因子：
2.4
通讯作者：
Holland, Christy K.
中科院分区：
文献类型：
--
作者：
Haworth, Kevin J.;Mast, T. Douglas;Holland, Christy K.
以前，被动空化成像是在连续波高强度聚焦超声热消融的背景下描述的。然而，这项技术具有潜在的用于脉冲波治疗的反馈机制，例如超声波介导的药物输送。本文报道了实验和模拟的结果，以证明利用脉冲超声辐射进行被动空化成像的可行性以及图像与脉冲超声参数的关系。被动空化图像是由在频域波束形成的通道数据形成的。实验在体外流动体模中进行，回声造影剂是一种实验性的回声造影剂，回声脂质体作为空化核。结果表明，脉冲宽度和包络对获得的图像分辨率影响很小。被动空化图像的幅度与空化发射能量成线性关系。可以从相同的接收数据集获得稳定空化和惯性空化的空化图像。(C)2012年美国声学学会。[http://dx.doi.org/10.1121/1.4728230]
Previously, passive cavitation imaging has been described in the context of continuous-wave high-intensity focused ultrasound thermal ablation. However, the technique has potential use as a feedback mechanism for pulsed-wave therapies, such as ultrasound-mediated drug delivery. In this paper, results of experiments and simulations are reported to demonstrate the feasibility of passive cavitation imaging using pulsed ultrasound insonations and how the images depend on pulsed ultrasound parameters. The passive cavitation images were formed from channel data that was beamformed in the frequency domain. Experiments were performed in an in vitro flow phantom with an experimental echo contrast agent, echogenic liposomes, as cavitation nuclei. It was found that the pulse duration and envelope have minimal impact on the image resolution achieved. The passive cavitation image amplitude scales linearly with the cavitation emission energy. Cavitation images for both stable and inertial cavitation can be obtained from the same received data set. (C) 2012 Acoustical Society of America. [http://dx.doi.org/10.1121/1.4728230]