ENDOCRINE RESPONSES TO MOTHER-INFANT SEPARATION IN DEVELOPING RATS
ENDOCRINE RESPONSES TO MOTHER-INFANT SEPARATION IN DEVELOPING RATS
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DOI：
10.1002/dev.420230503
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发表时间：
1990-07-01
影响因子：
2.2
通讯作者：
SCHANBERG, SM
中科院分区：
文献类型：
--
作者：
KUHN, CM;PAUK, J;SCHANBERG, SM
据报道，将新生大鼠幼崽与母体分离会引起幼崽的两种内分泌反应：生长激素分泌下降和皮质酮分泌上升。然而，这些反应的时间，个体发育和行为的决定因素还没有进行比较。在本研究中，我们报告说，这两种反应可以区分对这些标准。生长激素分泌福尔斯迅速下降后，立即从母鼠分离，而皮质酮分泌的强劲上升被推迟了许多小时。此外，生长激素反应在个体发育早期观察到。最后，积极的母性行为是需要正常的生长激素分泌在10天大的大鼠幼崽，而被动的感觉刺激与大坝可以显着降低皮质酮反应分离。
Separation of neonatal rat pups from the dam have been reported to elicit two endocrine responses in the pup: a fall in growth hormone secretion and a rise in corticosterone secretion. However, the temporal, ontogenetic, and behavioral determinants of these responses have not been compared. In the present study, we report that these two responses can be differentiated on each of these criteria. Growth hormone secretion falls rapidly immediately upon separation of pups from the dam, while robust rises in corticosterone secretion are delayed for many hours. In addition, growth hormone responses are observed earlier in ontogeny. Finally, active maternal behavior is required for normal growth hormone secretion in 10-day-old rat pups, while passive sensory stimuli associated with the dam can significantly reduce the corticosterone response to separation.