Hypotension preferentially induces c-fos immunoreactivity in supraoptic vasopressin neurons.
Hypotension preferentially induces c-fos immunoreactivity in supraoptic vasopressin neurons.
复制标题
低血压优先诱导视上加压素神经元中的 c-fos 免疫反应性。
DOI：
10.1016/0006-8993(92)91275-j
复制
发表时间：
1992
期刊：
影响因子：
2.9
通讯作者：
Dun,NJ
中科院分区：
文献类型：
--
作者：
Shen,E;Dun,SL;Ren,C;Bennett-Clarke,C;Dun,NJ
Immunoreactivity toFosprotein (Fos-IR) was detected in rat hypothalamic neurons within 1 h of onset of hemorrhage by withdrawing 4–5 ml of blood, which lowered the arterial blood pressure to 50–70 mm Hg. About 70% of vasopressin (AVP)-containing neurons in the supraoptic nucleus (SON) and 20% in the paraventricular nucleus (PVN) expressedFos-IR. In contrast, 5% of oxytocin (OXY)-containing neurons in the SON and <1 % in PVN wereFos-IR. Intravenous infusion of the vasodilating agent, nitroprusside, which lowered the blood pressure to levels comparable to that attained by hemorrhage, inducedFos-IR in greater than 655 of AVP-containing neurons in the SON, while relatively few AVP neurons in the PVN wereFospositive. These results suggest that hemorrhage or hypotension preferentially induces c-fosexpression in supraoptic AVP-containing neurons.
