Clinical implications of pachyvessels in polypoidal choroidal vasculopathy
Clinical implications of pachyvessels in polypoidal choroidal vasculopathy
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DOI：
10.1186/s12886-020-01443-8
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发表时间：
2020-04-29
影响因子：
2
通讯作者：
Ogata, Nahoko
中科院分区：
文献类型：
--
作者：
Ijuin, Nobuo;Tsujinaka, Hiroki;Ogata, Nahoko
背景 息肉状脉络膜血管病（PCV）是厚脉络膜谱系疾病中的一种疾病。粗血管的存在是粗脉络膜疾病的特征之一。然而，粗血管的存在与 PCV 眼的临床特征之间的关系尚未确定。本研究的目的是确定脉络膜粗血管的存在与患有 PCV 的眼睛的临床特征之间的关系。方法回顾了被诊断为 PCV 且未接受治疗的患者的病历。使用荧光素和吲哚菁绿血管造影、眼底摄影、谱域光学相干断层扫描（SD-OCT）和增强深度成像OCT（EDI-OCT）来获取脉络膜图像。通过 ICGA 图像确定病理性扩张的外脉络膜血管（粗血管）的存在。这些粗血管被证实与 EDI OCT 图像中的大脉络膜血管相对应。根据是否存在粗血管将 PCV 眼分为两组，并评估两组之间的临床特征和中心凹下脉络膜厚度 (SFCT)。结果对 84 名 PCV 患者的 86 只眼睛进行了评估。 48 只眼 (55.8%) 检测到粗血管。所有 86 只眼睛的平均 SFCT 为 203.9 +/- 83.9 μm，有粗血管 (+) 的眼睛明显比无粗血管 (-) 的眼睛薄（183.2 +/- 58.4 μm vs 230.2 +/- 103.1 μm；P = 0.01）。两组间视网膜下积液、色素上皮脱离和出血的发生率差异无显着性。然而，粗血管（+）出血组的PCV眼脉络膜最薄（P = 0.047）。对侧眼的脉络膜特征与PCV受影响眼的脉络膜特征相似，即，粗血管(+)组的对侧眼有粗血管，而粗血管(-)组的对侧眼没有粗血管。结论PCV眼出现粗血管的比例为55.8%，且SFCT较薄。粗血管的存在和内脉络膜的衰减可能是由于PCV眼部的病理变化所致。
Background Polypoidal choroidal vasculopathy (PCV) is one of the disorders within the pachychoroid spectrum diseases. The presence of pachyvessels is one of the characteristics of pachychoroid disorders. However, the relationship between the presence of pachyvessels and the clinical characteristics of PCV eyes has not been determined. The purpose of this study was to determine the relationship between the presence of choroidal pachyvessels and the clinical characteristics of eyes with PCV. Methods The medical records of patients who were diagnosed with PCV and were treatment-naive were reviewed. Fluorescein and indocyanine green angiography, fundus photography, spectral domain optical coherence tomography (SD-OCT), and enhanced depth imaging OCT (EDI-OCT) were used to obtain images of the choroid. The presence of pathologically dilated outer choroidal vessels, pachyvessels, was determined by ICGA images. These pachyvessels were confirmed to correspond with the large choroidal vessels in the EDI OCT images. The PCV eyes were divided into two groups based on the presence or absence of pachyvessels and clinical features and subfoveal choroidal thickness (SFCT) were evaluated between the two groups. Results Eighty-six eyes of 84 patients with PCV were evaluated. Pachyvessels were detected in 48 eyes (55.8%). The mean SFCT was 203.9 +/- 83.9 mu m in all 86 eyes, and it was significantly thinner in eyes with pachyvessels (+) than without pachyvessels (-) (183.2 +/- 58.4 mu m vs 230.2 +/- 103.1 mu m; P = 0.01). The differences in the incidence of subretinal fluid, pigment epithelial detachments, and hemorrhages between the two groups were not significant. However, the PCV eyes in pachyvessels (+) group with hemorrhage had the thinnest choroid (P = 0.047). The choroidal features of the fellow eyes were similar to those of the PCV affected eyes, that is, the fellow eyes in pachyvessels (+) group had pachyvessels and the fellow eyes in pachyvessels (-) group did not have pachyvessels. Conclusions Pachyvessels were presented 55.8% in eyes with PCV, and these eyes had the thin SFCT. The presence of pachyvessels and attenuation of the inner choroid were probably due to the pathological changes in the eyes with PCV.