Helicobacter pylori and autoimmune pancreatitis:: role of carbonic anhydrase via molecular mimicry?
Helicobacter pylori and autoimmune pancreatitis:: role of carbonic anhydrase via molecular mimicry?
复制标题
DOI：
10.1111/j.1582-4934.2005.tb00506.x
复制
发表时间：
2005-07-01
影响因子：
5.3
通讯作者：
Benvenga, S
中科院分区：
文献类型：
--
作者：
Guarneri, F;Guarneri, C;Benvenga, S
自身免疫性胰腺炎是最近定义的疾病分类学实体，其占所有形式的慢性胰腺炎的4.6-6%，并且通常与其他自身免疫性疾病，特别是干燥综合征相关。HLA-DRB 1 *0405-DQB 1 *0401基因型的携带者有发生自身免疫性胰腺炎的风险。针对碳酸酐酶II和乳铁蛋白的自身抗体经常存在于受影响的受试者中，并且被怀疑具有致病作用。幽门螺杆菌引起的胃感染与自身免疫性胰腺炎之间的联系已被推测。我们使用计算机蛋白质分析和搜索HLA结合基序来验证这一假设。我们发现人碳酸酐酶II和幽门螺杆菌的α-碳酸酐酶之间具有显着的同源性，该酶是胃环境中细菌存活和增殖的基础。此外，同源片段含有HLA分子DRB 1*0405的结合基序。我们的数据加强了胃幽门螺杆菌感染可引发遗传易感受试者自身免疫性胰腺炎的假设。
Autoimmune pancreatitis is a recently defined nosological entity, which accounts for 4.6-6% of all forms of chronic pancreatitis and is often associated with other autoimmune diseases, particularly Sjogren's syndrome. Possession of the HLA DRB1*0405-DQB1*0401 genotype confers a risk for the development of autoimmune pancreatitis. Autoantibodies against carbonic anhydrase II and lactoferrin are frequently present in affected subjects and are suspected to have a pathogenic role. A link between gastric infection by Helicobacter pylori and autoimmune pancreatitis has been hypothesized. We used in silico protein analysis and search for HLA binding motifs to verify this hypothesis. We found a significant homology between human carbonic anhydrase II and alpha-carbonic anhydrase of Helicobacter pylori, an enzyme which is fundamental for the survival and proliferation of the bacterium in the gastric environment. Moreover, the homologous segments contain the binding motif of the HLA molecule DRB 1*0405. Our data strengthen the hypothesis that gastric Helicobacter pylori infection can trigger autoimmune pancreatitis in genetically predisposed subjects.