Regulation of subtelomeric silencing during stress response
Regulation of subtelomeric silencing during stress response
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DOI：
10.1016/s1097-2765(02)00695-0
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发表时间：
2002-12-01
期刊：
影响因子：
16
通讯作者：
Zheng, XFS
中科院分区：
文献类型：
--
作者：
Ai, WD;Bertram, PG;Zheng, XFS
Sir proteins play a critical role in silent chromatin domains. While mutations can cause derepression of heterochromatin, it remains unclear whether silencing is actively involved in transcriptional control under changing environmental conditions. We find that TOR inhibits Sir3 phosphorylation. Rapamycin or stress induced by chlorpromazine leads to activation of MAP kinase Mpk1/Slt2, which phosphorylates Sir3. Sir3 hyperphosphorylation is correlated with reduced subtelomeric silencing, increased subtelomeric cell wall gene expression, and stress resistance to chlorpromazine, but does not affect the silent HML and rDNA loci. Based on these observations, we propose that regulation of silencing may be used to control gene expression at specific silent chromatin domains in response to stress and possibly other environmental changes.
