Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression
Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression
复制标题
DOI：
10.1037/1064-1297.5.2.107
复制
发表时间：
1997-05-01
影响因子：
2.3
通讯作者：
Lucki, I
中科院分区：
文献类型：
--
作者：
Detke, MJ;Johnson, J;Lucki, I
强迫游泳试验(FST)是一种在啮齿动物中广泛使用的行为筛查方法，对临床上有效的抗抑郁药物具有敏感性和选择性。然而，抗抑郁药物在治疗后24小时内会产生FST的变化，而从临床抑郁中恢复需要数周时间，而且在大多数动物试验中，似乎需要高剂量才能产生效果。这项研究检测了低剂量(1-5 mg/kg)抗抑郁药物在亚急性和慢性治疗后对FST的行为影响，以确定在亚急性治疗后无效的剂量的慢性治疗是否产生了行为影响。被研究的抗抑郁药物是选择性去甲肾上腺素摄取抑制剂地昔帕明和选择性5-羟色胺摄取抑制剂氟西汀。结果表明，小剂量地塞帕明和氟西汀在FST中产生不同的行为模式，但仅在长期给药后才出现。这些结果加强了FST作为抗抑郁药物行为筛查的有效性，这些药物的特征类似于抑郁症的动物模型。
The forced swimming test (FST) is a widely used behavioral screen in rodents that is both sensitive and selective for clinically effective antidepressant drugs. However, antidepressant drugs produce changes in the FST within 24 hr of treatment, in contrast to weeks required for the recovery from clinical depression and high doses seem to be required to produce effects in most animal tests. This study examined behavioral effects in the FST after subacute and chronic treatment with low doses (1-5 mg/kg) of antidepressant drugs to determine whether chronic treatment produced behavioral effects at doses that were ineffective after subacute treatment. The antidepressants studied were desipramine, a selective norepinephrine uptake inhibitor, and fluoxetine, a selective serotonin uptake inhibitor. The results indicated that low doses of desipramine and fluoxetine produced different behavioral patterns in the FST, but only after chronic administration. The results strengthen the validity of the FST as a behavioral screen for antidepressant drugs with features similar to an animal model of depression.