Recordings of renal and splanchnic sympathetic nervous activity in normotensive and spontaneously hypertensive rats.
Recordings of renal and splanchnic sympathetic nervous activity in normotensive and spontaneously hypertensive rats.
复制标题
正常血压和自发性高血压大鼠肾脏和内脏交感神经活动的记录。
作者：
P. Thoren;S.
1.在麻醉的成年自发性高血压（SH）大鼠和Wistar-Kyoto血压正常（WK）大鼠的左肾，从单个交感神经纤维获得记录。2.在对照条件下，SH大鼠的平均交感神经活性为3.3 +/- SE 0.45 Hz，WK大鼠为1.6 +/- 0.23 Hz。在去甲肾上腺素输注过程中，SH和WK大鼠的单纤维放电逐渐下降至低水平。纤维活性/mmHg动脉压升高的绝对减少在SH大鼠中比在WK大鼠中更大，但当放电减少表示为百分比变化时，情况正好相反。3.记录还获得了清醒的SH和WK大鼠的左内脏神经。在容量负荷与血液，在SH大鼠的交感神经活性下降显着超过WK大鼠。4.因此，SH大鼠对肾脏的交感神经放电高于WK大鼠。在容量负荷SH大鼠表现出夸张的反射反应，可能是由于一个增强的容量受体反应。
1. Recordings have been obtained from single sympathetic fibres to the left kidney in anaesthetized adult spontaneously hypertensive (SH) rats and Wistar-Kyoto normotensive (WK) rats. 2. Under control conditions SH rats had a mean sympathetic activity of 3.3 +/- SE 0.45 Hz and WK rats 1.6 +/- 0.23 Hz. During noradrenaline infusion single fibre discharge decreased gradually to low levels in both SH and WK rats. The absolute decrease in fibre activity/mmHg rise of arterial pressure was greater in SH rats than in WK rats, but the reverse was true when the discharge reduction was expressed as a percentage change. 3. Recordings have also been obtained from the left splanchnic nerve in awake SH and WK rats. Upon volume load with blood, in SH rats the sympathetic activity decreased significantly more than in WK rats. 4. Thus the sympathetic discharge to the kidneys is higher in SH rats than in WK rats. Upon volume load SH rats show an exaggerated reflex response, probably due to an augmented volume-receptor response.