Cytokinesis without myosin II
Cytokinesis without myosin II
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DOI：
10.1016/s0955-0674(99)00066-6
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发表时间：
2000-02-01
影响因子：
7.5
通讯作者：
Weber, I
中科院分区：
文献类型：
--
作者：
Gerisch, G;Weber, I
基质锚定的Dictyosteoblasts细胞分裂没有肌球蛋白II的能力打开了分析的可能性，在没有一个收缩环的丝状肌球蛋白和肌动蛋白的情况下形成的分裂沟。类似的可能性存在于芽殖酵母的突变体中，并且不严格地说，也存在于药物处理的哺乳动物细胞中。网柄藻中的肌球蛋白-II-独立的活动包括微管诱导的细胞表面编程为皱褶区域和转化为凹沟的区域，以及皮质素和交联膜蛋白向卵裂沟的易位。一个向心流动的肌动蛋白丝，然后在卵裂沟解体提出的易位的基础。
The ability of substrate-anchored Dictyostelium cells to divide without myosin II has opened the possibility of analysing the formation of cleavage furrows in the absence of a contractile ring made of filamentous myosin and actin. Similar possibilities exist in mutants of budding yeast and, less strictly, also in drug-treated mammalian cells. Myosin-II-independent activities in Dictyostelium include the microtubule-induced programming of the cell surface into ruffling areas and regions that are converted into a concave furrow, as well as the translocation of cortexillins and cross-linked membrane proteins towards the cleavage furrow. A centripetal flow of actin filaments followed by their disassembly in the cleavage furrow is proposed to underlie the translocation.