The Link between Facial Feedback and Neural Activity within Central Circuitries of Emotion-025EFNew Insights from Botulinum Toxin-Induced Denervation of Frown Muscles
The Link between Facial Feedback and Neural Activity within Central Circuitries of Emotion-025EFNew Insights from Botulinum Toxin-Induced Denervation of Frown Muscles
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DOI：
10.1093/cercor/bhn104
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发表时间：
2009-03-01
期刊：
影响因子：
3.7
通讯作者：
Haslinger, Bernhard
中科院分区：
文献类型：
--
作者：
Hennenlotter, Andreas;Dresel, Christian;Haslinger, Bernhard
来自肌肉和皮肤的传入反馈被认为会在控制面部表情的过程中影响我们的情绪。最近的成像研究表明，模仿面部表情与杏仁核等边缘区域的激活有关。然而，这种边缘系统激活和面部反馈之间的生理相互作用仍然不清楚。为了研究面部表情的有意模仿过程中面部反馈对边缘系统脑反应的影响，我们应用肉毒杆菌毒素（BTX）诱导的皱眉肌去神经支配结合功能性磁共振成像作为可逆损伤模型，以最大限度地减少传入肌肉和皮肤输入的发生。我们发现，在模仿愤怒的面部表情，减少反馈，由于BTX治疗减弱激活的左杏仁核和其功能耦合与脑干区域牵连在自主表现的情绪状态。这些发现表明，面部反馈调节神经活动的中央回路的情绪在故意模仿面部表情。鉴于人们倾向于模仿他人的情感表达，这可能为情感的社会转移提供了潜在的生理基础。
Afferent feedback from muscles and skin has been suggested to influence our emotions during the control of facial expressions. Recent imaging studies have shown that imitation of facial expressions is associated with activation in limbic regions such as the amygdala. Yet, the physiological interaction between this limbic activation and facial feedback remains unclear. To study if facial feedback effects on limbic brain responses during intentional imitation of facial expressions, we applied botulinum toxin (BTX)-induced denervation of frown muscles in combination with functional magnetic resonance imaging as a reversible lesion model to minimize the occurrence of afferent muscular and cutaneous input. We show that, during imitation of angry facial expressions, reduced feedback due to BTX treatment attenuates activation of the left amygdala and its functional coupling with brain stem regions implicated in autonomic manifestations of emotional states. These findings demonstrate that facial feedback modulates neural activity within central circuitries of emotion during intentional imitation of facial expressions. Given that people tend to mimic the emotional expressions of others, this could provide a potential physiological basis for the social transfer of emotion.