Sox11 promotes endogenous neurogenesis and locomotor recovery in mice spinal cord injury
Sox11 promotes endogenous neurogenesis and locomotor recovery in mice spinal cord injury
复制标题
Sox11促进小鼠脊髓损伤的内源性神经发生和运动恢复
DOI：
10.1016/j.bbrc.2014.02.103
复制
发表时间：
2014-04-18
影响因子：
3.1
通讯作者：
Yang, Jie
中科院分区：
文献类型：
--
作者：
Guo, Yuji;Liu, Shangming;Yang, Jie
我们将含有Sox 11基因的慢病毒载体引入小鼠脊髓损伤中，以评估Sox 11在脊髓损伤中的治疗潜力。Sox 11显著改善脊髓损伤后的运动恢复，并且这种恢复伴随着损伤脊髓中Nestin/Doublecortin表达的上调。Sox 11主要定位于中央管的内源性神经干细胞和脊髓新生神经元中。此外，Sox 11显著诱导LV-Sox 11处理小鼠脊髓中BDNF的表达。我们的结论是，Sox 11诱导内源性神经干细胞的激活，进入神经元的决定和迁移损伤脊髓内。损伤部位BDNF的增加可能形成一个独特的神经原性小生境，诱导这些神经干细胞的最终神经元分化。通过增强Sox 11的表达诱导内源性神经干细胞向神经源性细胞分化，可能成为脊髓损伤后恢复性治疗的一个有前景的策略。(C)由Elsevier Inc.出版。
We introduced a lentiviral vector containing the Sox11 gene into injured spinal cords of mice to evaluate the therapeutic potential of Sox11 in spinal cord injury. Sox11 markedly improved locomotor recovery after spinal cord injury and this recovery was accompanied by an up-regulation of Nestin/Doublecortin expression in the injured spinal cord. Sox11 was mainly located in endogenous neural stem cells lining the central canal and in newly-generated neurons in the spinal cord. In addition, Sox 11 significantly induced expressions of BDNF in the spinal cords of LV-Sox11-treated mice. We concluded that Sox11 induced activation of endogenous neural stem cells into neuronal determination and migration within the injured spinal cord. The resultant increase of BDNF at the injured site might form a distinct neurogenic niche which induces a final neuronal differentiation of these neural stem cells. Enhancing Sox11 expression to induce neurogenic differentiation of endogenous neural stem cells after injury may be a promising strategy in restorative therapy after SCI in mammals. (C) 2014 Published by Elsevier Inc.