The synthesis of water soluble prodrugs analogs of echinocandin B.
The synthesis of water soluble prodrugs analogs of echinocandin B.
复制标题
棘白菌素 B 水溶性前药类似物的合成。
DOI：
10.1016/s0960-894x(99)00290-5
复制
发表时间：
1999
影响因子：
2.7
通讯作者：
W. Turner
中科院分区：
文献类型：
--
作者：
M. Rodriguez;V. Vasudevan;J. Jamison;P. Borromeo;W. Turner
报道了两种棘白菌素半合成衍生物酚羟基上膦酸酯和磷酸酯前药的简便合成方法。ECB化合物的水溶性和稳定性特征随所用烷基的选择而变化。在某些情况下，具有小脂肪族侧链的酯前药保留抗真菌活性，同时提高水溶性。
A facile synthesis of phosphonate and phosphate ester prodrugs on the phenolic hydroxy of two echinocandin semisynthetic derivatives is reported. The water solubility and stability profiles of the ECB compounds varied with the choice of alkyl group used. In some cases, the ester prodrugs with small aliphatic side chains retained antifungal activity while enhancing water solubility.