Spiral imaging in fMRI.

Spiral imaging in fMRI.
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DOI:
10.1016/j.neuroimage.2011.10.039
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发表时间:
2012-08-15
期刊:
影响因子:
5.7
通讯作者:
Glover, Gary H.
Glover, Gary H.
中科院分区:
医学1区
文献类型:
--
作者:
Glover, Gary H.

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T2* 加权血氧水平相关 (BOLD) 功能磁共振成像 (fMRI) 需要高效的采集方法,以便在几秒的时间段内对大脑进行充分采样。最广泛使用的方法是回波平面成像 (EPI),它利用笛卡尔轨迹覆盖 k 空间。该轨迹受到来自非共振和梯度缺陷的重影的影响,并且本质上对来自 k 空间原点附近梯度波形的大量一阶和高阶矩的心脏引起的脉动运动敏感。此外,只有读出方向梯度对轨迹贡献显着的能量。相比之下,螺旋方法使用阿基米德或类似轨迹对 k 空间进行采样,该轨迹从 k 空间中心开始并螺旋到边缘(螺旋出),或其相反,在原点结束(螺旋入)。螺旋方法降低了对运动的敏感度,缩短了读出时间,改善了大多数额叶和顶叶大脑区域的信号恢复,并表现出模糊伪影而不是重影或几何失真。结合螺旋入和螺旋出轨迹的方法在减少磁敏度引起的信号丢失和增加 BOLD 信号方面具有进一步的优势。在 8 名受试者的时间信噪比测量中,与 EPI 相比,Spiral-in/out 在额叶和整个大脑区域恢复的体素体积显着增加(分别为 18% 和 10%)。
T2*-weighted Blood Oxygen Level Dependent (BOLD) functional magnetic resonance imaging (fMRI) requires efficient acquisition methods in order to fully sample the brain in a several second time period. The most widely used approach is Echo Planar Imaging (EPI), which utilizes a Cartesian trajectory to cover k-space. This trajectory is subject to ghosts from off-resonance and gradient imperfections and is intrinsically sensitive to cardiac-induced pulsatile motion from substantial first- and higher order moments of the gradient waveform near the k-space origin. In addition, only the readout direction gradient contributes significant energy to the trajectory. By contrast, the Spiral method samples k-space with an Archimedean or similar trajectory that begins at the k-space center and spirals to the edge (Spiral-out), or its reverse, ending at the origin (Spiral-in). Spiral methods have reduced sensitivity to motion, shorter readout times, improved signal recovery in most frontal and parietal brain regions, and exhibit blurring artifacts instead of ghosts or geometric distortion. Methods combining Spiral-in and Spiral-out trajectories have further advantages in terms of diminished susceptibility-induced signal dropout and increased BOLD signal. In measurements of temporal signal to noise ratio measured in 8 subjects, Spiral-in/out exhibited significant increases over EPI in voxel volumes recovered in frontal and whole brain regions (18% and 10%, respectively).
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