Inflammatory signaling and cellular senescence.
Inflammatory signaling and cellular senescence.
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DOI：
10.1016/j.cellsig.2008.10.011
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发表时间：
2009-03
影响因子：
4.8
通讯作者：
Han J
中科院分区：
文献类型：
--
作者：
Ren JL;Pan JS;Lu YP;Sun P;Han J
炎症在癌症发病过程中是一把双刃剑。炎症反应在消除潜在的癌细胞中起着关键作用。然而，炎症微环境也促进了癌症的发展。促炎细胞因子是炎症的关键介质，在肿瘤发生中也起双重作用。虽然它们可以促进肿瘤进展，但最近的研究揭示了炎症途径在抑制癌症发展方面的意想不到的功能。这些研究表明，经历衰老的细胞（一种作为癌症发展屏障的细胞程序）会产生更多的炎症细胞因子。这些炎性细胞因子在细胞衰老的启动和维持中起着至关重要的作用，并负责触发先天免疫反应，清除体内衰老的肿瘤细胞。本文就衰老细胞产生的炎性细胞因子在癌症发病中的双重作用及其介导细胞衰老的信号通路进行综述。
Inflammation is a double-edged sword in the pathogenesis of cancer. Inflammatory responses play a key role in eliminating the potentially cancerous cells. However, inflammatory microenvironment also promotes the development of cancer. Pro-inflammatory cytokines, the key mediators of inflammation, also play a dual role in oncogenesis. While they can promote neoplastic progression, recent studies have revealed an unexpected function of the inflammatory pathways in inhibiting cancer development. These studies demonstrate that cells undergoing senescence, a cellular program serving as a barrier to cancer development, produce increased amount of inflammatory cytokines. These inflammatory cytokines play an essential role in the initiation and maintenance of cellular senescence, and is responsible for triggering an innate immune response that clears the senescent tumor cells in vivo. The purpose of the present review is to discuss the dual roles of the inflammatory cytokines produced by senescent cells in the pathogenesis of cancer, and the signaling pathway mediating their role in cellular senescence.
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影响因子：
11.2
作者：
Bavik, C;Coleman, I;Nelson, PS
通讯作者：
Nelson, PS
影响因子：
64.8
作者：
Bartkova, Jirina;Rezaei, Nousin;Gorgoulis, Vassilis G.
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Gorgoulis, Vassilis G.
影响因子：
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影响因子：
10.5
作者：
Ancrile, Brooke;Lim, Kian-Huat;Counter, Christopher M.
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影响因子：
5.3
作者：
Ferbeyre, G;de Stanchina, E;Lowe, SW
通讯作者：
Lowe, SW