Association of office-based frailty score with hypertensive end organ damage in the J-SHIPP cross-sectional study.
Association of office-based frailty score with hypertensive end organ damage in the J-SHIPP cross-sectional study.
复制标题
J-SHIPP 横断面研究中办公室衰弱评分与高血压终末器官损伤的关联。
DOI：
10.1016/j.ijcard.2016.04.135
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发表时间：
2016
影响因子：
3.5
通讯作者：
Michiya Igase
中科院分区：
文献类型：
--
作者：
Tabara Yasuharu;Katsuhiko Kohara;Masayuki Ochi;Yoko Okada;Maya Ohara;Tokihisa Nagai;Michiya Igase
背景虚弱是一种反映生理储备减少和脆弱性增加的老年综合征，是心血管疾病发病率和死亡率的独立危险因素。然而，脆弱和高血压终末器官损害之间的关系是不完全established.Method和resultsWe进行了一项横断面研究，探讨脆弱和终末器官损害之间的关联在1125明显健康的中年到老年人受试者。我们进行了一个简单的虚弱（SF）评分，这是很容易在办公室获得，结合低手握力和短单腿站立（OLS）时间。评估SF评分与高血压终末器官损伤和其他虚弱相关参数之间的相关性。SF评分1与评分0对高血压存在的比值比为1.9 [1.4-2.5，p < .0001]，SF评分2的比值比为3.3 [2.1-5.3，p < .0001]。SF评分与臂踝脉搏波传导速度（baPWV）和中心脉压（PP 2）也显著相关。SF评分与由21个参数计算的较高虚弱指数、较低认知测试评分、%肺活量、骨骼肌质量和大腿肌肉横截面积显著相关。SF评分与脑白色质高密度分期、血浆B型利钠肽水平和尿蛋白排泄量呈正相关，即使校正包括baPWV和PP 2在内的混杂参数后也是如此。SF评分可能是一个有用的临床工具，以确定体弱的受试者和先进的终末器官损害的老年受试者。
BackgroundFrailty, a geriatric syndrome reflecting a state of reduced physiological reserve and increased vulnerability, is an independent risk factor for cardiovascular morbidity and mortality. However, the relationship between frailty and hypertensive end-organ damage is not fully established.Method and resultsWe performed a cross-sectional study to investigate the association between frailty and end-organ damage in 1125 apparently healthy middle-aged to elderly subjects. We performed a simple frailty (SF) score that was easily obtainable in the office, in combination with low hand grip power and short one-leg standing (OLS) time. The association between SF score and hypertensive end-organ damage and other frailty-related parameters was evaluated. Odds ratio of SF score 1 to score 0 for the presence of hypertension was 1.9 [1.4–2.5, p < .0001] and that of SF score 2 was 3.3 [2.1–5.3, p < .0001]. SF score was also significantly associated with brachial-ankle pulse wave velocity (baPWV) and central pulse pressure (PP2). SF score was significantly associated with higher frailty index calculated from 21 parameters, lower cognitive test score, % vital capacity, skeletal muscle mass, and thigh muscle cross-sectional area. SF score was positively associated with stage of brain white matter hyperintenisty, plasma levels of B-type natriuretic peptide, and urinary protein excretion, even after correction for confounding parameters including baPWV and PP2.ConclusionsThese findings indicate that frailty is significantly associated with end-organ damage in elderly subjects. SF score may be a useful clinical tool to identify frail subjects and advanced end-organ damage in elderly subjects.