Central hyperexcitability triggered by noxious inputs.
Central hyperexcitability triggered by noxious inputs.
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DOI：
10.1016/0959-4388(93)90062-4
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发表时间：
1993-08-01
影响因子：
5.7
通讯作者：
Wall, P D
中科院分区：
文献类型：
--
作者：
McMahon, S B;Lewin, G R;Wall, P D
电刺激、组织损伤或神经损伤引起的无髓鞘感觉传入神经元的重复活动可诱导背角神经元的持久敏化。这一过程可被NMDA受体拮抗剂阻断。在过去的一年中，已经出现了感觉神经肽和一氧化氮也是这种现象的重要介质。
Repetitive activity in unmyelinated sensory afferent neurones, arising from electrical stimuli, tissue injury or nerve damage, can induce long-lasting sensitization in dorsal horn neurones. This process can be blocked by antagonists of the NMDA receptor. In the past year it has emerged that sensory neuropeptides and nitric oxide are also essential mediators of this phenomenon.