Organization of partner preference and sexual behavior and its nocturnal rhythmicity in male rats.
Organization of partner preference and sexual behavior and its nocturnal rhythmicity in male rats.
复制标题
雄性大鼠伴侣偏好和性行为的组织及其夜间节律。
作者：
J. Bakker;J. van Ophemert;A. Slob
从第0天、第2天或第5天到第14天，雄性大鼠接受1,4,6-雄甾烷-3,17-二酮（ATD）治疗，该药物可阻断睾酮(T)向雌二醇（E2）的芳香化。在光-暗（LD）周期的暗期前期，研究了成体伴侣偏好行为（PPB，发情雌性大鼠[F]和活跃雄性大鼠[M]之间的选择）。ATD第0天表现出对刺激M的偏好或对刺激s的不偏好。对照组表现出对刺激性f的偏好。ATD第2天和第5天表现出介于ATD第0天和对照组之间的PPB。因此，新生儿对成人PPB组织的敏感期超过了第5天。此外，PPB在ATD患者中显示夜间节律性，而在对照组中没有。在暗期后期，所有Ms均表现出对刺激F的偏好。ATD第2天和第5天Ms与对照Ms在PPB中不再存在差异，但ATD第0天Ms对F的偏好得分仍显著低于其他Ms。因此，T的E2代谢物抑制了PPB中成人夜间节律的组织。
Male rats were neonatally treated with 1,4,6-androstatriene-3,17-dione (ATD), which blocks aromatization of testosterone (T) to estradiol (E2), from Days 0, 2, or 5 through 14. Adult partner preference behavior (PPB; choice between estrous female rat [F] and active male rat [M]) was studied in the early part of the dark phase of the light-dark (LD) cycle. ATD Day 0 Ms showed a preference for the stimulus M or showed no preference for either of the stimulus Ss. Controls preferred the estrous F. ATD Days 2 and 5 Ms showed PPB intermediate between ATD Day 0 Ms and controls. Thus the neonatally sensitive period for organization of adult PPB extends beyond Day 5. Furthermore, PPB showed a nocturnal rhythmicity in ATD Ms but not in controls. In the late part of the dark phase, all Ms showed a preference for the stimulus F. ATD Days 2 and 5 Ms and control Ms were no longer different in PPB, but ATD Day 0 Ms still showed significantly lower preference scores for F than all other Ms. Thus the E2 metabolite of T suppresses organization of an adult nocturnal rhythm in PPB.