Genetic influences on the augmentation of natural killer (NK) cells during murine cytomegalovirus infection: correlation with patterns of resistance.
Genetic influences on the augmentation of natural killer (NK) cells during murine cytomegalovirus infection: correlation with patterns of resistance.
复制标题
鼠巨细胞病毒感染期间遗传对自然杀伤（NK）细胞增强的影响：与耐药模式的相关性。
作者：
G. Bancroft;G. Shellam;J. Chalmer
小鼠巨细胞病毒（MCMV）感染后，小鼠脾脏中自然杀伤细胞（NK）的细胞毒活性增强。早在病毒给药后10小时就观察到刺激，但刺激取决于所使用的剂量，特别是宿主基因型。效应细胞能够杀死一系列肿瘤细胞靶点以及正常的同基因胸腺细胞，并在裸（nu/nu）和杂合（nu/+）小鼠中诱导。在所检测的11个菌株中，有10个菌株对MCMV感染致死效应的抗性与该病毒增强NK细胞的程度之间存在显著相关性。非H-2相关的活性差异被观察到，但高NK细胞反应和拥有特定的H-2单倍型之间的明确关联并不明显。米色突变体C57BL/6J小鼠，先前报道为NK细胞功能缺陷，易受MCMV感染，在感染期间表达低水平的细胞毒性。因此，在MCMV感染的早期阶段，NK细胞的遗传控制刺激可能有助于该病毒的基因型相关抗性模式。
Cytotoxic activity attributable to natural killer (NK) cells was augmented in the spleens of mice infected with murine cytomegalovirus (MCMV). Stimulation was observed as early as 10 hr after virus administration but was dependent upon the dose used, and in particular, the host genotype. Effector cells were capable of killing a range of tumor cell targets as well as normal syngeneic thymocytes, and were induced in nude (nu/nu) and heterozygous (nu/+) mice. A significant correlation existed between resistance to the lethal effects of MCMV infection and the degree of NK cell augmentation by this virus in 10 of 11 strains examined. Non-H-2 related differences in activity were observed, but a clear association between high NK cell responses and the possession of a particular H-2 haplotype was not apparent. Beige mutant C57BL/6J mice, previously reported as defective in NK cell function were susceptible to MCMV and expressed low levels of cytotoxicity during infection. Thus, the genetically controlled stimulation of NK cells in the early stages of infection with MCMV may contribute to the genotype related patterns of resistance seen with this virus.