MicroRNAs: opening a new vein in angiogenesis research.
MicroRNAs: opening a new vein in angiogenesis research.
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DOI：
10.1126/scisignal.252pe1
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发表时间：
2009-01-06
影响因子：
7.3
通讯作者：
Srivastava D
中科院分区：
文献类型：
--
作者：
Fish JE;Srivastava D
内皮细胞中血管生成程序的激活对于正常胚胎发育和成人中的生理性血管生成至关重要。此外，血管生成是一个重要的治疗目标：新血管的形成是再生目的所需的，例如在组织愈合或移植期间，但可能是病理性的，如糖尿病视网膜病变和癌症。血管内皮对血管生成刺激的反应由称为microRNA的非编码RNA调节。内皮细胞特异性microRNA microRNA-126（miR-126）通过抑制信号转导途径的负调节因子，响应血管生成生长因子（如血管内皮生长因子或碱性成纤维细胞生长因子）促进血管生成。另外的microRNA已经涉及血管生成的各个方面的调节。因此，靶向microRNA的表达可能是一种新的治疗方法，涉及过多或不足的血管疾病。
Activation of the angiogenic program in endothelial cells is vital for normal embryonic development and for physiological angiogenesis in the adult. In addition, angiogenesis is an important therapeutic target: Formation of new blood vessels is desirable for regenerative purposes, such as during tissue healing or transplantation, but can be pathological, as in diabetic retinopathy and cancer. The response of the vascular endothelium to angiogenic stimuli is modulated by noncoding RNAs called microRNAs. The endothelial cell–specific microRNA microRNA-126 (miR-126) promotes angiogenesis in response to angiogenic growth factors, such as vascular endothelial growth factor or basic fibroblast growth factor, by repressing negative regulators of signal transduction pathways. Additional microRNAs have been implicated in the regulation of various aspects of angiogenesis. Thus, targeting the expression of microRNAs may be a novel therapeutic approach for diseases involving excess or insufficient vasculature.
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