Interfacing Biomaterials with Synthetic T Cell Immunity.
Interfacing Biomaterials with Synthetic T Cell Immunity.
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DOI：
10.1002/adhm.202100157
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发表时间：
2021-08
影响因子：
10
通讯作者：
Kwong GA
中科院分区：
文献类型：
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作者：
Su FY;Mac QD;Sivakumar A;Kwong GA
The clinical success of cancer immunotherapy is providing exciting opportunities for the development of new methods to detect and treat cancer more effectively. A new generation of biomaterials is being developed to interface with molecular and cellular features of immunity and ultimately shape or control anti-tumor responses. This review focuses on recent advances that are supporting the advancement of engineered T cells. This class of cancer therapy has the potential to cure disease in subsets of patients, yet there remain challenges such as the need to improve response rates and safety while lowering costs to expand their use. To provide a focused overview, we highlight recent strategies in three areas of biomaterials research: low-cost cell manufacturing to broaden patient access, noninvasive diagnostics for predictive monitoring of immune responses, and strategies for in vivo control that enhance anti-tumor immunity. These research efforts shed light on some of the challenges associated with T cell immunotherapy and how engineered biomaterials that interface with synthetic immunity are gaining traction to solve these challenges. Biomaterials that interface with synthetic T cell immunity have the potential to detect and treat cancer more effectively. This review highlights recent advances in three areas of biomaterials research to improve engineered T cell therapies: low-cost manufacturing, predictive monitoring, and in vivo control.
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12.8
作者：
Cartellieri M;Feldmann A;Koristka S;Arndt C;Loff S;Ehninger A;von Bonin M;Bejestani EP;Ehninger G;Bachmann MP
通讯作者：
Bachmann MP
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Rosenberg, SA
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