Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study
Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study
复制标题
DOI：
10.1136/ard.2005.045724
复制
发表时间：
2007-07-01
影响因子：
27.4
通讯作者：
Pols, H. A. P.
中科院分区：
文献类型：
--
作者：
Dahaghin, S.;Bierma-Zeinstra, S. M. A.;Pols, H. A. P.
背景资料：由于手关节是非承重的，因此超重和手骨关节炎（HOA）之间的关联对于理解除了轴向负荷之外超重如何与骨关节炎（OA）相关联是至关重要的。超重可能通过其他代谢因素与OA的发生有关。目的：为了评估超重在HOA中的作用，使用了基于人群的研究的横断面数据（≥ 55岁，n = 3585）。研究了糖尿病、高血压和总胆固醇：高密度脂蛋白（HDL）-胆固醇比率对HOA的作用，以及它们是否在超重/ HOA的关联中起中间作用。结果：在不考虑其他代谢因素的情况下，超重（体重指数（BMI）为27.4 kg/m2）与HOA显著相关（OR 1.4，95%CI 1.2 ~ 1.7）。糖尿病和HOA之间的关联仅存在于55 - 62岁的人群中（OR 1.9，95%CI 1.0 - 3.8），但在总人群或其他年龄组中不存在。高血压与HOA的相关性很弱，在调整BMI后消失。总胆固醇/ HDL胆固醇比值与HOA无显著相关性。超重、糖尿病和高血压的同时存在导致HOA的患病率更高（OR 2.3，95% CI 1.3 - 3.9）;年轻组的患病率进一步增加（OR 3.2，95% CI 1.1至8.8）。没有发现代谢因素对超重与HOA之间的关系有中间影响。然而，当超重与高血压和糖尿病一起发生时，特别是在相对年轻的时候，似乎存在。
Background: As hand joints are non- weight bearing, the association between overweight and hand osteoarthritis ( HOA) is critical to understanding how overweight may associate with osteoarthritis ( OA) apart from axial load. Overweight might be associated with the occurrence of OA through other metabolic factors.Aim: To evaluate the role of overweight in HOA, cross- sectional data of a population- based study were used (>= 55 years, n = 3585). The role of diabetes, hypertension and total cholesterol: high- density lipoprotein ( HDL)- cholesterol ratio on HOA, and whether they play an intermediate role in the association of overweight/ HOA was investigated. Furthermore, the prevalence of HOA in the concurrent presence of overweight and other metabolic factors was evaluated.Results: Independently of other metabolic factors, overweight ( body mass index ( BMI).27.4 kg/ m(2)) showed a significant association with HOA ( OR 1.4, 95% CI 1.2 to 1.7). The association between diabetes and HOA was only present in people aged 55 - 62 years ( OR 1.9, 95% CI 1.0 to 3.8), but was absent in the total population or in other age groups. The association of hypertension with HOA was weak, and disappeared after adjustment for BMI. The total/ HDL cholesterol ratio showed no significant association with HOA. The concurrent presence of overweight, diabetes and hypertension resulted in an even higher prevalence of HOA ( OR 2.3, 95% CI 1.3 to 3.9) compared with subjects with none of these characteristics; this prevalence increased further in the younger age group ( OR 3.2, 95% CI 1.1 to 8.8).Conclusion: No intermediate effect of metabolic factors on the association of overweight with HOA was found. An increase in the prevalence of HOA, however, seems to be present when overweight occurs together with hypertension and diabetes especially at a relatively young age.