THE INHERITANCE OF LEFT-VENTRICULAR STRUCTURE AND FUNCTION ASSESSED BY IMAGING AND DOPPLER ECHOCARDIOGRAPHY
THE INHERITANCE OF LEFT-VENTRICULAR STRUCTURE AND FUNCTION ASSESSED BY IMAGING AND DOPPLER ECHOCARDIOGRAPHY
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DOI：
10.1016/0002-8703(91)90021-9
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发表时间：
1991-06-01
影响因子：
4.8
通讯作者：
AMERY, A
中科院分区：
文献类型：
--
作者：
BIELEN, E;FAGARD, R;AMERY, A
本文应用M型超声心动图和多普勒超声心动图对53对18 ~ 31岁的同卵双胞胎左室结构和功能的遗传度进行了研究。 左室壁厚度的表型方差的一个显着部分解释了遗传方差。 然而，对于左心室内部尺寸，在校正体重后没有发现遗传效应。 经过适当调整后，发现主动脉峰值流速的遗传成分为32%，每搏距离为55%，每分钟距离为47%。 二尖瓣舒张早期和晚期峰值流速显示遗传成分估计分别为43%和26%。 舒张晚期/早期峰值流速比的遗传率估计为53%。 总之，这些数据表明，左心室结构特征，但不是腔尺寸的一个显着的遗传成分。 遗传对左心室流入和流出特性有显著影响。
The heritability of left ventricular structure and function was studied in 53 pairs of monozygotic and dizygotic twins, aged 18 to 31 years, by means of M-mode and Doppler echocardiography. A significant fraction of the phenotypic variances of left ventricular wall thickness was explained by genetic variance. For the left ventricular internal dimension, however, no genetic effect was found after correction for body weight. After appropriate adjustment a genetic component of 32% was found for aortic peak flow velocity, 55% for stroke distance, and 47% for minute distance. The early and late diastolic peak flow velocities at the mitral valve showed a genetic component estimated at 43% and 26%, repectively. The inheritance of the late/early diastolic peak flow velocity ratio was estimated at 53%. In conclusion, these data suggest a significant genetic component for left ventricular structural features but not for cavity dimension. A significant influence of heredity was detected for left ventricular inflow and outflow characteristics.