Robust conjunctive item-place coding by hippocampal neurons parallels learning what happens where.
Robust conjunctive item-place coding by hippocampal neurons parallels learning what happens where.
复制标题
DOI：
10.1523/jneurosci.1378-09.2009
复制
发表时间：
2009-08-05
期刊：
影响因子：
--
通讯作者：
Eichenbaum H
中科院分区：
文献类型：
--
作者：
Komorowski RW;Manns JR;Eichenbaum H
先前的研究表明，海马体在事件发生的背景下在记忆中起着关键作用。然而，迄今为止的研究还没有提供令人信服的证据表明海马神经元编码与这种学习直接相关的事件上下文连接。在这里，我们报告说，动物学习不同的意义的项目在不同的情况下，个别海马神经元发展的具体刺激的地方，他们有不同的意义。此外，这种合取编码在预先存在的空间表示的子集内以增强的项目特定响应的形式演变。这些发现支持了海马体中的连接表征是获得特定背景记忆的基础的观点。
Previous research indicates a critical role of the hippocampus in memory for events in the context in which they occur. However, studies to date have not provided compelling evidence that hippocampal neurons encode event-context conjunctions directly associated with this kind of learning. Here we report that, as animals learn different meanings for items in distinct contexts, individual hippocampal neurons develop responses to specific stimuli in the places where they have differential significance. Furthermore, this conjunctive coding evolves in the form of enhanced item-specific responses within a subset of the pre-existing spatial representation. These findings support the view that conjunctive representations in the hippocampus underlie the acquisition of context specific memories.