Anatomical MRI study of borderline personality disorder patients
Anatomical MRI study of borderline personality disorder patients
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DOI：
10.1016/j.pscychresns.2004.04.003
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发表时间：
2004-07-30
影响因子：
2.3
通讯作者：
Soares, JC
中科院分区：
文献类型：
--
作者：
Brambilla, P;Soloff, PH;Soares, JC
据报道，边缘型人格障碍（BPD）患者的海马体积减少，并被假设与创伤性童年经历有关。我们扩展了这项研究，以探索BPD患者大脑结构变化的其他脑区域和其他潜在的临床相关性。10名未服药的BPD受试者和20名健康对照者被评估了当前和过去的轴I和II合并症和童年虐待史。所有患者均采用1.5 T GE信号成像系统进行磁共振成像（MRI）研究，进行三维梯度回波成像（SPGR），参数为TR=25 ms， TE=5 ms，切片厚度=1.5 mm。与健康对照组相比，BPD患者的左右海马体积明显减小，在儿童期受虐者中最为明显，而右侧和左侧壳核体积显著增加，特别是在物质使用障碍者中。尾状核、杏仁核、颞叶、背外侧前额叶皮层和脑总容量组间无显著差异。这项研究重复了先前的发现，即BPD患者的海马体积减少。此外，在BPD中发现壳核体积增加，这一发现以前没有报道过。早期创伤经历可能在海马萎缩中起作用，而物质使用障碍可能导致壳核增大。2004爱思唯尔爱尔兰有限公司版权所有。
Hippocampal volume reduction has been reported in patients with borderline personality disorder (BPD), and is hypothesized to be associated with traumatic childhood experiences. We extended this investigation to explore additional brain regions and other potential clinical correlates of structural brain changes in BPD. Ten unmedicated BPD subjects and 20 healthy controls were assessed for current and past Axis I and II comorbidities and histories of childhood abuse. All had magnetic resonance imaging (MRI) studies with a 1.5 T GE Signa Imaging System, performing three-dimensional-gradient echo imaging (SPGR) with the following parameters: TR=25 ms, TE=5 ms, and slice-thickness=1.5 mm. Compared with healthy controls, BPD subjects had significantly smaller right and left hippocampal volumes, most marked in subjects with childhood abuse, and significantly increased right and left putamen volumes, especially in subjects with substance use disorders. No significant differences between groups were found for caudate, amygdala, temporal lobes, dorsolateral prefrontal cortex and total brain volumes. This study replicated prior findings of diminished hippocampal volumes in subjects with BPD. Also, increased putamen volumes were found in BPD, a finding that has not been previously reported. Early traumatic experiences may play a role in hippocampal atrophy, whereas substance use disorders may contribute to putamen enlargement. (C) 2004 Elsevier Ireland Ltd. All rights reserved.