Biocompatible hybrid silica nanobiocomposites for the efficient delivery of anti-staphylococcal drugs
Biocompatible hybrid silica nanobiocomposites for the efficient delivery of anti-staphylococcal drugs
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DOI：
10.1016/j.ijpharm.2016.03.037
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发表时间：
2016-08-30
影响因子：
5.8
通讯作者：
Bolocan, Alexandra
中科院分区：
文献类型：
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作者：
Balaure, Paul Catalin;Popa, Raisa Anamaria;Bolocan, Alexandra
这项工作报告了非表面活性剂模板合成和表征的一种新的酪氨酸-二氧化硅/抗生素（TyR-SiO2/ATBs）纳米复合材料，以及在体外和体内的细胞毒性和抗微生物活性对微生物病原体金黄色葡萄球菌。体外微生物学实验表明，该纳米生物结构能显著增强三种常用抗生素对沙门氏菌的抗菌活性。金黄色葡萄球菌（即红霉素（ERI）、庆大霉素（GEN）和氯唑西林（CLO））的生长抑制作用，如生长抑制区直径增加和最小抑制浓度值降低所揭示的，以及亚致死抗生素浓度对各致病菌株粘附和定殖不同基质的能力的抑制作用所揭示的。这些结果与缺乏对间充质干细胞的毒性沿着适当的体内生物分布相关，突出了这种载体有希望的治疗潜力，其允许减少所需的活性剂量，同时显著减轻药物对宿主生物体的有害副作用。(C)© 2016 Elsevier B. V.版权所有。
This work reports the non-surfactant templated synthesis and characterization of a new tyrosine-silica/antibiotics (TyR-SiO2/ATBs) nanocomposite, as well as both in vitro and in vivo cytotoxicity and antimicrobial activity against the microbial pathogen Staphylococcus aureus. The in vitro microbiological tests proved that the obtained nanobiostructure significantly enhance the antimicrobial activity of three commonly used antibiotics against S. aureus (i.e. erythromycin (ERI), gentamicin (GEN), and cloxacillin (CLO)) as revealed by the increased diameters of the growth inhibition zones and the decreased minimal inhibitory concentration values, as well as by the inhibitory effect of sub-lethal antibiotic concentrations on the ability of the respective pathogenic strains to adhere and colonize different substrata. These results, correlated with the lack of toxicity against mesenchymal stem cells along with an appropriate in vivo biodistribution highlight the promising therapeutic potential of this carrier that allows a decrease of the required active doses while significantly lessening the harmful side effects of the medication on the host organism. (C) 2016 Elsevier B.V. All rights reserved.