Sarcopenic Obesity in Liver Cirrhosis: Possible Mechanism and Clinical Impact.
Sarcopenic Obesity in Liver Cirrhosis: Possible Mechanism and Clinical Impact.
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DOI：
10.3390/ijms22041917
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发表时间：
2021-02-15
影响因子：
5.6
通讯作者：
Iijima H
中科院分区：
文献类型：
--
作者：
Nishikawa H;Enomoto H;Nishiguchi S;Iijima H
近年来，慢性肝病(CLDs)的情况发生了很大的变化。其中之一是非酒精性脂肪性肝病的增加。如今，越来越多的慢性肝病患者，甚至是那些患有肝硬变(LC)的患者，都倾向于出现肥胖。随着肝脏储备的恶化，每年的肌肉损失率增加，因此LC患者更有可能并发骨质疏松症。LC的特点还包括蛋白质-能量营养不良(PEM)。由于LC的PEM可以是恒定的，患者可能存在骨质疏松症(Sa-O)，既包括骨质疏松症，也包括肥胖症。目前，指南中没有提到Sa-O；然而，Sa-O迅速增加的患病率和较差的临床后果被认为是一个重要的公共卫生问题，Sa-O的诊断价值预计将在未来增加。SA-O涉及一种复杂的生理机制相互作用，包括炎性细胞因子增加、氧化应激、胰岛素抵抗、激素紊乱和体力活动下降。SA-O在LC中的发病机制是多种多样的，在肌肉-肝脏-脂肪组织轴上有许多扰动。在此，我们将对Sa-O的现有知识进行综述，尤其是对LC。
The picture of chronic liver diseases (CLDs) has changed considerably in recent years. One of them is the increase of non-alcoholic fatty liver disease. More and more CLD patients, even those with liver cirrhosis (LC), tend to be presenting with obesity these days. The annual rate of muscle loss increases with worsening liver reserve, and thus LC patients are more likely to complicate with sarcopenia. LC is also characterized by protein-energy malnutrition (PEM). Since the PEM in LC can be invariable, the patients probably present with sarcopenic obesity (Sa-O), which involves both sarcopenia and obesity. Currently, there is no mention of Sa-O in the guidelines; however, the rapidly increasing prevalence and poorer clinical consequences of Sa-O are recognized as an important public health problem, and the diagnostic value of Sa-O is expected to increase in the future. Sa-O involves a complex interplay of physiological mechanisms, including increased inflammatory cytokines, oxidative stress, insulin resistance, hormonal disorders, and decline of physical activity. The pathogenesis of Sa-O in LC is diverse, with a lot of perturbations in the muscle–liver–adipose tissue axis. Here, we overview the current knowledge of Sa-O, especially focusing on LC.
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影响因子：
8
作者：
Hammad, Ahmed;Kaido, Toshimi;Uemoto, Shinji
通讯作者：
Uemoto, Shinji
影响因子：
3
作者：
Elswefy, Sahar El-Sayed;Abdallah, Fatma Rizk;Hasan, Rehab Abdallah
通讯作者：
Hasan, Rehab Abdallah
影响因子：
7.6
作者：
Han, E.;Lee, Y. -H.;Kim, S. U.
通讯作者：
Kim, S. U.
DOI：
10.1002/jcsm.12269
发表时间：
2018-04
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Bering T;Diniz KGD;Coelho MPP;Vieira DA;Soares MMS;Kakehasi AM;Correia MITD;Teixeira R;Queiroz DMM;Rocha GA;Silva LD
通讯作者：
Silva LD
影响因子：
5.9
作者：
Albano, Domenico;Messina, Carmelo;Sconfienza, Luca Maria
通讯作者：
Sconfienza, Luca Maria