Blood stasis syndrome in Japan and its molecular biological analysis
Blood stasis syndrome in Japan and its molecular biological analysis
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DOI：
10.1007/s11655-014-1882-7
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发表时间：
2014-07-01
影响因子：
2.9
通讯作者：
Goto, Hirozo
中科院分区：
文献类型：
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作者：
Goto, Hirozo
血瘀证是东方传统医学的病理概念之一。在东方传统医学中，血液不仅被认为是血液，而且被认为是身体的活的组成部分。事实上，血瘀证不仅与循环障碍有关，还与皮肤病和妇科等疾病有关。在日本，血瘀证的概念是基于过去的文献，如《金匮要略》等。血瘀证的症状有很多，如口干，腹部饱胀，皮肤粗糙。然而，这些迹象的重要程度一直不清楚。因此，为了确定严重程度，Terasawa博士基于多变量分析制定了血瘀证评分系统（Terasawa血瘀评分）。运用现代分析技术，对血瘀证进行了以血液循环为主的研究。结果表明，血瘀证患者存在血液流变学异常，经活血化瘀方治疗后，这些异常均有改善。并从分子生物学角度对血瘀证进行了研究。通过蛋白质组学分析寻找血瘀证的特异性蛋白质表达，未发现特异性蛋白质表达。然而，通过构建决策树来开发血瘀症的诊断算法可能是有可能的。缺氧诱导因子作为影响血瘀证的分子生物学因素之一，位于许多基因的上游，近年来一直是我们研究的热点。首先，血瘀证不仅仅是循环功能障碍，而是包括生命体不断多边变化的病理概念。
Blood stasis syndrome is one of the pathological concepts of Oriental traditional medicine. In Oriental traditional medicine, blood is thought of as not only blood but also as a living component of the body. In fact, blood stasis syndrome is related to not just circulation disorders but dermatological and gynecological and other diseases. In Japan, the concept of blood stasis syndrome is based on the past literature, for instance, Synopsis of Golden Chamber (Jin Kui Yao Lue), etc. There are many signs of this syndrome, such as a dry mouth, fullness of the abdomen and rough skin. However, the levels of importance of these signs had been unclear. Therefore, in order to determine the levels of seriousness, a scoring system of blood stasis syndrome was made based on multivariate analysis by Dr. Terasawa (Terasawa's Blood Stasis Score). Using the scoring system, we have studied blood stasis syndrome mainly related to blood circulation using modern techniques of analysis. From the results, we found that patients with blood stasis syndrome showed hemorheological abnormalities, and an improvement in these abnormalities was shown after administration of removing-blood stasis formulae. Furthermore, we have studied blood stasis syndrome from the point of view of molecular biology. We searched for the specific protein expression in blood stasis syndrome by proteomic analysis, and found no specific protein expression. However, there may be a possibility of developing a diagnostic algorithm for blood stasis by construction of a decision tree. During the past few years, as one of the molecular biological factors affecting blood stasis syndrome, we have been studying hypoxia inducible factor, which is located in the upstream of many genes. Above all, blood stasis syndrome is more than just circulatory deficit but encompasses the pathological concept of constant multilateral change in the living body.