PO MYELIN PROTEIN PRODUCES EXPERIMENTAL ALLERGIC NEURITIS IN LEWIS RATS
PO MYELIN PROTEIN PRODUCES EXPERIMENTAL ALLERGIC NEURITIS IN LEWIS RATS
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DOI：
10.1016/0022-510x(87)90235-8
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发表时间：
1987-07-01
影响因子：
4.4
通讯作者：
HUGHES, RAC
中科院分区：
文献类型：
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作者：
MILNER, P;LOVELIDGE, CA;HUGHES, RAC
以牛脊髓根髓磷脂为原料制备Po蛋白。经十二烷基硫酸钠-聚丙烯酰胺凝胶电泳（SDS-PAGE）和亲和纯化抗血清免疫染色证实其纯度。存在溶血磷脂酰胆碱的Po诱导Lewis大鼠麻痹和类似实验性过敏性神经炎的组织学病变。溶血磷脂酰胆碱也增强了P2产生神经炎的能力。这些蛋白的构象在决定它们诱导实验性过敏性神经炎的能力方面可能是重要的。Po作为一种与格林-巴利综合征相关的抗原值得考虑。
Po protein was prepared from bovine spinal root myelin. The purity was shown by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunostaining with affinity purified antisera. Po in the presence of lysophosphatidylcholine induced paralysis and histological lesions resembling experimental allergic neuritis in Lewis rats. Lysophosphatidylcholine also enhanced the ability of P2 to produce neuritis. The conformation of these proteins may be important in determining their ability to induce experimental allergic neuritis. Po deserves consideration as an antigen relevant to Guillain-Barre syndrome.