Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso
Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso
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DOI：
10.1186/1475-2875-11-79
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发表时间：
2012-03-22
期刊：
影响因子：
3
通讯作者：
Sirima, Sodiomon B.
中科院分区：
文献类型：
--
作者：
Diarra, Amidou;Nebie, Issa;Sirima, Sodiomon B.
背景：患者的免疫状态被认为会影响抗疟疾化疗的疗效。这是一个很重要的问题，因为免疫相关相互作用的证据可能会影响我们在耐药人群中使用化疗，以及对次优疫苗价值的评估。研究目的是探讨抗体与抗疟疾药物治疗效果之间的关系。方法：在疟疾高发季节前对248名0.5 ~ 15岁儿童进行调查。采用ELISA法从每个儿童身上采集静脉血（5ml），测定对选定疟疾抗原的抗体水平。还进行了血液涂片以评估药物疗效和疟疾感染流行率。积极随访儿童，记录临床疟疾病例。结果：治疗成功组MSP3 IgG水平均高于治疗失败组。对GLURP进行了相同的观察，但对MSP1-19进行了相反的观察。除IgG4对MSP1-19和GLURP的保护作用外，嗜细胞抗体和非嗜细胞抗体与所有三种抗原的保护作用显著相关。结论：获得性抗疟抗体可能对低龄易患儿童抗疟药物的疗效起重要作用。
Background: Patient immune status is thought to affect the efficacy of anti-malarial chemotherapy. This is a subject of some importance, since evidence of immunity-related interactions may influence our use of chemotherapy in populations with drug resistance, as well as assessment of the value of suboptimal vaccines. The study aim was to investigate relationship between antibodies and anti-malarial drug treatment outcomes.Methods: Some 248 children aged 0.5 and 15 years were recruited prior to the high malaria transmission season. Venous blood (5 ml) was obtained from each child to measure antibody levels to selected malaria antigens, using ELISA. Blood smears were also performed to assess drug efficacy and malaria infection prevalence. Children were actively followed up to record clinical malaria cases.Results: IgG levels to MSP3 were always higher in the successfully treated group than in the group with treatment failure. The same observation was made for GLURP but the reverse observation was noticed for MSP1-19. Cytophilic and non-cytophilic antibodies were significantly associated with protection against all three antigens, except for IgG4 to MSP1-19 and GLURP.Conclusion: Acquired anti-malarial antibodies may play an important role in the efficacy of anti-malarial drugs in younger children more susceptible to the disease.